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Protein Page:
CDK2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDK2 a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276 Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Kinase, protein; Protein kinase, CMGC; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: Cajal body; centrosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; endosome; nucleoplasm; nucleus
Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process: centriole replication; centrosome duplication; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA replication; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; meiosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; peptidyl-serine phosphorylation; positive regulation of cell proliferation; Ras protein signal transduction; regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Reference #:  P24941 (UniProtKB)
Alt. Names/Synonyms: cdc2-related protein kinase; CDK2; cell devision kinase 2; Cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2)
Gene Symbols: CDK2
Molecular weight: 33,930 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDK2

Protein Structure Not Found.