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Protein Page:
JARID1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
JARID1A Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Interacts with SUZ12; the interaction is direct. Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Nuclear receptor co-regulator; EC 1.14.11.-; Nucleolus; Oxidoreductase
Chromosomal Location of Human Ortholog: 12p11
Cellular Component: cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function: chromatin DNA binding; DNA binding; histone demethylase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein binding; transcription coactivator activity; transcription factor activity; zinc ion binding
Biological Process: circadian regulation of gene expression; male gonad development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; spermatogenesis; transcription from RNA polymerase II promoter
Reference #:  P29375 (UniProtKB)
Gene Symbols: KDM5A
Molecular weight: 192,095 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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JARID1A

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K45‑ub RIRPLAEktGICKIR
0 1 T46‑p IRPLAEktGICKIRP
0 1 T84 LNELEAMTRVRLDFL
0 1 K106‑ub ELQGSTLkIPVVERK
0 1 S121 ILDLYALSKIVASKG
0 1 S126 ALSKIVASKGGFEMV
0 1 T134‑p KGGFEMVtKEKKWSK
0 1 K152‑ub RLGYLPGkGTGSLLK
0 1 S160‑p GTGSLLKsHyERILY
0 1 Y162‑p GSLLKsHyERILYPY
0 1 T203‑p VLSTDTQtsPEPGTR
0 9 S204‑p LSTDTQtsPEPGTRM
0 1 K222‑ub PKRTRRVkTQsESGD
0 3 T223 KRTRRVkTQsESGDV
0 1 S225‑p TRRVkTQsESGDVSR
0 1 K347‑ub CVAEECSkPREAFGF
0 2 S399‑p KEFWRLVsSIEEDVI
0 2 K425‑ub FGSGFPVkDGRRKIL
0 1 T918‑p LSDPQQVtLDVMKkL
0 1 K924‑ac VtLDVMKkLIDSGVG
0 3 S970‑p LQARPRHsVAsLESI
0 1 S973‑p RPRHsVAsLESIVNE
0 1 S1066‑p RTFLKKNsSHtLLQV
0 1 T1069‑p LKKNsSHtLLQVLsP
0 2 S1075‑p HtLLQVLsPRTDIGV
0 1 S1085 TDIGVYGSGKNRRKK
0 33 S1111‑p DLDLEPLsDLEEGLE
0 1 S1143‑p KEIEAMHsLRAANLA
0 1 S1280‑p LAKLSVLsQRMVEQA
0 2 S1327‑p AFNRVVSsVsssPRQ
0 1 S1329‑p NRVVSsVsssPRQTM
0 2 S1330‑p RVVSsVsssPRQTMD
0 7 S1331‑p VVSsVsssPRQTMDY
0 1 Y1338 sPRQTMDYDDEEtDs
0 6 T1343‑p MDYDDEEtDsDEDIR
0 6 S1345‑p YDDEEtDsDEDIRET
0 1 K1382‑sm CDEEIPIkSEEVVTH
0 1 S1410‑p SSASKSCsQGSstPR
0 1 S1414‑p KSCsQGSstPRKQPR
0 4 T1415‑p SCsQGSstPRKQPRK
0 5 S1423‑p PRKQPRKsPLVPRSL
0 3 S1438‑p EPPVLELsPGAKAQL
0 1 S1476 LQATHPPSEDRFLHI
0 8 S1488‑p LHIMEDDsMEEKPLK
0 1 K1532 KELKKMDKPRKKKLK
0 1 S1579‑p KVELVKEsTEKKREK
0 2 Y1595 VLDIPSKYDWsGAEE
0 11 S1598‑p IPSKYDWsGAEEsDD
0 10 S1603‑p DWsGAEEsDDENAVC
0 12 S1666‑p AKKQGPVsPGPAPPP
0 1 S1674‑p PGPAPPPsFIMSYKL
  JARID1A iso2  
K45 RIRPLAEKTGICKIR
T46 IRPLAEKTGICKIRP
T84 LNELEAMTRVRLDFL
K106 ELQGSTLKIPVVERK
S121 ILDLYALSKIVASKG
S126 ALSKIVASKGGFEMV
T134 KGGFEMVTKEKKWSK
K152 RLGYLPGKGTGSLLK
S160 GTGSLLKSHYERILY
Y162 GSLLKSHYERILYPY
T203 VLSTDTQTSPEPGTR
S204 LSTDTQTSPEPGTRM
K222 PKRTRRVKTQSESGD
T223 KRTRRVKTQSESGDV
S225 TRRVKTQSESGDVSR
K347 CVAEECSKPREAFGF
S399 KEFWRLVSSIEEDVI
K425 FGSGFPVKDGRRKIL
T918 LSDPQQVTLDVMKKL
K924 VTLDVMKKLIDSGVG
S970 LQARPRHSVASLESI
S973 RPRHSVASLESIVNE
S1066 RTFLKKNSSHTLLQV
T1069 LKKNSSHTLLQVLSP
S1075 HTLLQVLSPRTDIGV
S1085 TDIGVYGSGKNRRKK
S1111 DLDLEPLSDLEEGLE
S1143 KEIEAMHSLRAANLA
S1280 LAKLSVLSQRMVEQA
S1327 AFNRVVSSVSSSPRQ
S1329 NRVVSSVSSSPRQTM
S1330 RVVSSVSSSPRQTMD
S1331 VVSSVSSSPRQTMDY
Y1338 SPRQTMDYDDEETDS
T1343 MDYDDEETDSDEDIR
S1345 YDDEETDSDEDIRET
K1382 CDEEIPIKSEEVVTH
S1410 SSASKSCSQGSSTPR
S1414 KSCSQGSSTPRKQPR
T1415 SCSQGSSTPRKQPRK
S1423 PRKQPRKSPLVPRSL
S1438 EPPVLELSPGAKAQL
S1476 LQATHPPSEDRFLHI
S1488 LHIMEDDSMEEKPLK
K1532 KELKKMDKPRKKKLK
S1579 KVELVKESTEKKREK
Y1595 VLDIPSKYDWSGAEE
S1598 IPSKYDWSGAEESDD
S1603 DWSGAEESDDENAVC
- gap
- gap
  mouse

 
K45 RIRPFAEKTGICKIR
T46 IRPFAEKTGICKIRP
T84‑p LNELEAMtRVRLDFL
K106 ELQGSTLKIPVVERK
S121‑p ILDLYALsKIVAsKG
S126‑p ALsKIVAsKGGFEIV
T134 KGGFEIVTKEKKWSK
K152 RLGYLPGKGTGSLLK
S160 GTGSLLKSHYERILY
Y162 GSLLKSHYERILYPY
P203 VLSTDIQPsPERGTR
S204‑p LSTDIQPsPERGTRM
K222 PKRTRRVKsQSDSGE
S223‑p KRTRRVKsQSDSGEV
S225 TRRVKsQSDSGEVNR
K347 CVAEECNKPREAFGF
S399 KEFWRLVSSIEEDVI
K425 FGSGFPKKDGQRKML
T918 LSDPQQVTLDVMKKL
K924 VTLDVMKKLIDSGVG
S970 LQARPRHSMANLENI
N973 RPRHSMANLENIVNE
S1066 RTFLKKNSSHTLLQV
T1069 LKKNSSHTLLQVLSP
S1075 HTLLQVLSPRTDIGV
S1085‑p TDIGVYGsGKNRRKK
S1111‑p DLDLEPLsDLEEGLE
S1143 KEIEAMHSLRAANLA
S1280 LAKLSVLSQRMVEQA
S1327 AFNRVVSSVSSsPHQ
S1329 NRVVSSVSSsPHQTM
S1330 RVVSSVSSsPHQTMD
S1331‑p VVSSVSSsPHQTMDy
Y1338‑p sPHQTMDyDDEEtDs
T1343‑p MDyDDEEtDsDEDIR
S1345‑p yDDEEtDsDEDIRET
K1382 CDEEIPIKSEEVVTH
S1410 SSASKSCSQGSSTPR
S1414 KSCSQGSSTPRKQPR
T1415 SCSQGSSTPRKQPRK
S1423‑p PRKQPRKsPLVPRSL
S1438 EPPVLELSPGAKAQL
S1476‑p LQATHPPsEDRFLHI
S1488 LHIMEDDSIEEKPLK
K1532‑ac KELKKIDkPKKKKLK
S1579 KVELVKESTEKKRER
Y1595‑p VLDIPSKyDWsGAEE
S1598‑p IPSKyDWsGAEEsDD
S1603‑p DWsGAEEsDDENAVC
S1666‑p AKKQGPDsPGQAPPP
P1674 PGQAPPPPFLMSYKL
  rat

 
K45 RIRPLAEKTGICKIR
T46 IRPLAEKTGICKIRP
T84 LNELEAMTRVRLDFL
K106 ELQGSTLKIPVVERK
S121 ILDLYALSKIVASKG
S126 ALSKIVASKGGFEIV
T134 KGGFEIVTKEKKWSK
K152 RLGYLPGKGTGSLLK
S160 GTGSLLKSHYERILY
Y162 GSLLKSHYERILYPY
P203 VLSTDIQPsPERGTR
S204‑p LSTDIQPsPERGTRM
K222 PKRTRRVKSQSDSGE
S223 KRTRRVKSQSDSGEV
S225 TRRVKSQSDSGEVNR
K347 CVAEECNKPREAFGF
S399 KEFWRLVSSIEEDVI
K425 FGSGFPIKDGQRKML
T918 LSDPQQVTLDVMKKL
K924 VTLDVMKKLIDSGVG
S970 LQARPRHSMANLENI
N973 RPRHSMANLENIVNE
S1066 RTFLKKNSSHTLLQV
T1069 LKKNSSHTLLQVLSP
S1075 HTLLQVLSPRTDIGV
S1085 TDIGVYGSGKNRRKK
S1111‑p DLDLEPLsDLEEGLE
S1143 KEIEAMHSLRAANLA
S1280 LAKLSVLSQRMVEQA
S1327 AFNRVVSSVSSSPHQ
S1329 NRVVSSVSSSPHQAM
S1330 RVVSSVSSSPHQAMD
S1331 VVSSVSSSPHQAMDY
Y1338 SPHQAMDYDDEETDS
T1343 MDYDDEETDSDEDIR
S1345 YDDEETDSDEDIRET
K1382 CDEEIPIKSEEVVTH
S1410 SSASKSCSQGSSTPR
S1414 KSCSQGSSTPRKQPR
T1415 SCSQGSSTPRKQPRK
S1423 PRKQPRKSPLVPRSL
S1438 EPPVLELSPGAKAQL
S1476 LQATHPPSEDRFLHI
S1488‑p LHIMEDDsVEEKPLK
K1532 KELKKIDKPKKKKLK
S1579 KVELAKESTEKKRER
Y1595 VLDIPSKYDWSGAEE
S1598 IPSKYDWSGAEESDD
S1603 DWSGAEESDDENAVC
S1666 AKKQGPDSPGHAPPP
P1674 PGHAPPPPFIMSYKL
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