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Protein Page:
YY1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
YY1 a polycomb-group (Pc-G) protein essential for early mammalian development and the regulation of X-inactivation and certain imprinted genes. Required for the transactivation of TSIX by CTCF. The complex of CTCF-YY1-TSIX is a critical regulator of the X chromosome binary switch. Can function as an activator or a repressor depending on the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 14q
Cellular Component: nucleus
Molecular Function: DNA binding; four-way junction DNA binding; protein binding; RNA binding; SMAD binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: double-strand break repair via homologous recombination; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to UV-C
Reference #:  P25490 (UniProtKB)
Alt. Names/Synonyms: DELTA; Delta transcription factor; INO80 complex subunit S; INO80S; NF-E1; Transcriptional repressor protein YY1; TYY1; UCRBP; Yin and yang 1; Yin and Yang 1 protein; yin yang 1; YIN-YANG-1; YY-1; YY1; YY1 transcription factor
Gene Symbols: YY1
Molecular weight: 44,713 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

YY1

Protein Structure Not Found.
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Sites Implicated In
transcription, inhibited: Y383‑p
activity, inhibited: Y383‑p
intracellular localization: T348‑p, T378‑p
molecular association, regulation: S180‑p, S184‑p, T348‑p, T378‑p
protein stabilization: S118‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y8‑p MASGDTLyIATDGSE
1 0 T30 LHEIEVETIPVETIE
1 0 T39‑p PVETIETtVVGEEEE
1 25 S118‑p EVVGGDDsDGLRAED
0 1 S165‑p KSGGGGSsSSGGGRV
0 1 K174‑ac SGGGRVKkGGGKKsG
1 0 S180‑p KkGGGKKsGKksyLs
0 1 K183 GGKKsGKKsyLsGGA
0 1 K183‑sm GGKKsGKksyLsGGA
1 3 S184‑p GKKsGKksyLsGGAG
0 1 Y185‑p KKsGKksyLsGGAGA
0 6 S187‑p sGKksyLsGGAGAAG
0 5 K203‑ac GGADPGNkkWEQkQV
0 1 K203‑ub GGADPGNkkWEQkQV
0 1 K203‑sm GGADPGNkkWEQkQV
0 1 K204‑ac GADPGNkkWEQkQVQ
0 1 K208‑ub GNkkWEQkQVQIKTL
0 1 S225‑p EFSVTMWssDEKKDI
0 1 S226‑p FSVTMWssDEKKDID
1 30 S247‑p EQIIGENsPPDySEy
0 2 Y251‑p GENsPPDySEyMTGk
0 1 S252 ENsPPDySEyMTGkK
1 1 Y254‑p sPPDySEyMTGkKLP
0 1 K258‑ac ySEyMTGkKLPPGGI
0 1 K258‑ub ySEyMTGkKLPPGGI
0 1 K286‑sm FARMKPRkIkEDDAP
0 1 K288‑ub RMKPRkIkEDDAPRT
1 1 K288‑sm RMKPRkIkEDDAPRT
0 1 K305‑ub CPHKGCTkMFRDNsA
0 2 S311‑p TkMFRDNsAMRKHLH
0 1 K332‑ub HVCAECGkAFVESSk
0 3 K339‑ac kAFVESSkLKRHQLV
1 15 T348‑p KRHQLVHtGEkPFQC
0 6 K351‑ac QLVHtGEkPFQCTFE
1 7 S365‑p EGCGKRFsLDFNLRT
1 47 T378‑p RTHVRIHtGDRPyVC
1 0 Y383‑p IHtGDRPyVCPFDGC
0 1 S397 CNKKFAQSTNLkSHI
0 1 T398 NKKFAQSTNLkSHIL
0 1 K401‑ub FAQSTNLkSHILTHA
0 1 K401‑sm FAQSTNLkSHILTHA
0 1 S402 AQSTNLkSHILTHAk
0 2 K409‑ub SHILTHAkAKNNQ__
  mouse

 
Y8 MASGDTLYIATDGSE
T30‑p LHEIEVEtIPVETIE
T39 PVETIETTVVGEEEE
S120‑p EVVGGDDsDGLRAED
A165 AGKSGGGASSGGGRV
K174 SGGGRVKKGGGKKSG
S180 KKGGGKKSGKkSYLG
K183‑ub GGKKSGKkSYLGGGA
K183 GGKKSGKKSYLGGGA
S184 GKKSGKkSYLGGGAG
Y185 KKSGKkSYLGGGAGA
G187 SGKkSYLGGGAGAAG
K203 GGADPGNKKWEQKQV
K203 GGADPGNKKWEQKQV
K203 GGADPGNKKWEQKQV
K204 GADPGNKKWEQKQVQ
K208 GNKKWEQKQVQIKTL
S225 EFSVTMWSSDEKKDI
S226 FSVTMWSSDEKKDID
S247‑p EQIIGENsPPDYsEY
Y251 GENsPPDYsEYMTGK
S252‑p ENsPPDYsEYMTGKK
Y254 sPPDYsEYMTGKKLP
K258 YsEYMTGKKLPPGGI
K258 YsEYMTGKKLPPGGI
K286 FARMKPRKIKEDDAP
K288 RMKPRKIKEDDAPRT
K288 RMKPRKIKEDDAPRT
K305 CPHKGCTKMFRDNsA
S311‑p TKMFRDNsAMRKHLH
K332 HVCAECGKAFVESSK
K339 KAFVESSKLKRHQLV
T348‑p KRHQLVHtGEKPFQC
K351 QLVHtGEKPFQCTFE
S365‑p EGCGKRFsLDFNLRT
T378‑p RTHVRIHtGDRPYVC
Y383 IHtGDRPYVCPFDGC
S397‑p CNKKFAQstNLKsHI
T398‑p NKKFAQstNLKsHIL
K401 FAQstNLKsHILTHA
K401 FAQstNLKsHILTHA
S402‑p AQstNLKsHILTHAK
K409 sHILTHAKAKNNQ__
  rat

 
Y8 MASGDTLYIATDGSE
T30 LHEIEVETIPVETIE
T39 PVETIETTVVGEEED
S117‑p EVVGGDDsDGLRAED
S162 AGKSGGGSSSGGGRV
K171 SGGGRVKKGGGKKSG
S177 KKGGGKKSGKKSYLG
K180 GGKKSGKKSYLGSGA
K180 GGKKSGKKSYLGSGA
S181 GKKSGKKSYLGSGAG
Y182 KKSGKKSYLGSGAGA
G184 SGKKSYLGSGAGAAG
K200 GGADPGNKKWEQKQV
K200 GGADPGNKKWEQKQV
K200 GGADPGNKKWEQKQV
K201 GADPGNKKWEQKQVQ
K205 GNKKWEQKQVQIKTL
S222 EFSVTMWSSDEKKDI
S223 FSVTMWSSDEKKDID
S244‑p EQIIGENsPPDYSEY
Y248 GENsPPDYSEYMTGK
S249 ENsPPDYSEYMTGKK
Y251 sPPDYSEYMTGKKLP
K255 YSEYMTGKKLPPGGI
K255 YSEYMTGKKLPPGGI
K283 FARMKPRKIKEDDAP
K285 RMKPRKIKEDDAPRT
K285 RMKPRKIKEDDAPRT
K302 CPHKGCTKMFRDNSA
S308 TKMFRDNSAMRKHLH
K329 HVCAECGKAFVESSk
K336‑ac KAFVESSkLKRHQLV
T345 KRHQLVHTGEKPFQC
K348 QLVHTGEKPFQCTFE
S362 EGCGKRFSLDFNLRT
T375 RTHVRIHTGDRPYVC
Y380 IHTGDRPYVCPFDGC
S394 CNKKFAQSTNLKSHI
T395 NKKFAQSTNLKSHIL
K398 FAQSTNLKSHILTHA
K398 FAQSTNLKSHILTHA
S399 AQSTNLKSHILTHAK
K406 SHILTHAKAKNNQ__
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