a polycomb-group (Pc-G) protein essential for early mammalian development and the regulation of X-inactivation and certain imprinted genes. Required for the transactivation of TSIX by CTCF. The complex of CTCF-YY1-TSIX is a critical regulator of the X chromosome binary switch. Can function as an activator or a repressor depending on the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor
Molecular Function: DNA binding; four-way junction DNA binding; histone deacetylase binding; protein binding; RNA binding; SMAD binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding
Biological Process: anterior/posterior pattern formation; camera-type eye morphogenesis; cell differentiation; chromosome organization and biogenesis; double-strand break repair via homologous recombination; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to UV-C; RNA localization; spermatogenesis; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.