a component of the 40S ribosomal subunit of eukaryotes. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Overexpressed in colorectal cancer. Note: This description may include information from UniProtKB.
Protein type: Ribosomal; RNA-binding; Apoptosis; Translation; EC 18.104.22.168
Molecular Function: damaged DNA binding; DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; endodeoxyribonuclease activity; enzyme binding; Hsp70 protein binding; Hsp90 protein binding; iron-sulfur cluster binding; kinase binding; microtubule binding; mRNA binding; NF-kappaB binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; oxidized pyrimidine DNA binding; protein binding; protein kinase A binding; protein kinase binding; RNA binding; structural constituent of ribosome; SUMO binding; transcription factor binding; tubulin binding
Biological Process: activation of NF-kappaB transcription factor; cell division; cellular protein metabolic process; chromosome segregation; DNA damage response, detection of DNA damage; DNA repair; gene expression; mitosis; mRNA catabolic process, nonsense-mediated decay; negative regulation of DNA repair; negative regulation of protein ubiquitination; negative regulation of translation; positive regulation of DNA repair; positive regulation of endodeoxyribonuclease activity; positive regulation of JNK activity; positive regulation of microtubule polymerization; regulation of apoptosis; response to DNA damage stimulus; response to oxidative stress; selenium metabolic process; selenocysteine metabolic process; spindle assembly; SRP-dependent cotranslational protein targeting to membrane; transcription, DNA-dependent; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.