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Protein Page:
calpastatin (human)

Overview
calpastatin Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 5q15
Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; endoplasmic reticulum; membrane
Molecular Function: endopeptidase inhibitor activity; protein binding
Disease: Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Reference #:  P20810 (UniProtKB)
Alt. Names/Synonyms: BS-17; Calpain inhibitor; Calpastatin; CAST; heart-type calpastatin; ICAL; MGC9402; Sperm BS-17 component
Gene Symbols: CAST
Molecular weight: 76,573 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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calpastatin

Protein Structure Not Found.
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