Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA repair, damage; EC 220.127.116.11; Methyltransferase; Nuclear receptor co-regulator