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Protein Page:
MGMT (human)

Overview
MGMT Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA repair, damage; EC 2.1.1.63; Methyltransferase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: membrane; nucleoplasm; nucleus
Molecular Function: damaged DNA binding; DNA binding; DNA-methyltransferase activity; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity
Biological Process: DNA dealkylation; DNA ligation; negative regulation of apoptosis
Reference #:  P16455 (UniProtKB)
Alt. Names/Synonyms: 6-O-methylguanine-DNA methyltransferase; Methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase
Gene Symbols: MGMT
Molecular weight: 21,646 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MGMT

Protein Structure Not Found.
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