Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll
Molecular Function: ferric iron binding; ferroxidase activity; iron ion binding; protein binding
Biological Process: cellular iron ion homeostasis; immune response; intracellular sequestering of iron ion; iron ion transport; negative regulation of cell proliferation; negative regulation of fibroblast proliferation; post-Golgi vesicle-mediated transport; receptor-mediated endocytosis; transmembrane transport
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.