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Protein Page:
Securin (human)

Overview
Securin Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Oncoprotein
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: cytoplasm; cytosol
Molecular Function: protease inhibitor activity; protein binding; transcription factor activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; homologous chromosome segregation; protein ubiquitination during ubiquitin-dependent protein catabolic process; spermatogenesis; transcription from RNA polymerase II promoter
Reference #:  O95997 (UniProtKB)
Alt. Names/Synonyms: EAP1; Esp1-associated protein; ESP1-associated protein 1; hPTTG; MGC126883; MGC138276; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Securin; Tumor-transforming protein 1; TUTR1
Gene Symbols: PTTG1
Molecular weight: 22,024 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Securin

Protein Structure Not Found.


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