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Protein Page:
CCND3 (human)

Overview
CCND3 Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/p27Kip1, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/p27Kip1 required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either p21Cip1 or CDKN2A. Belongs to the cyclin family. Cyclin D subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 6p21
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytoplasm; focal adhesion; nucleoplasm; plasma membrane
Molecular Function: cyclin-dependent protein kinase activity; protein binding; protein kinase binding
Biological Process: cell cycle; cell division; positive regulation of cyclin-dependent protein kinase activity; positive regulation of protein amino acid phosphorylation; signal transduction; T cell proliferation
Reference #:  P30281 (UniProtKB)
Alt. Names/Synonyms: CCND3; cyclin D3; D3-type cyclin; G1/S-specific cyclin D3; G1/S-specific cyclin-D3
Gene Symbols: CCND3
Molecular weight: 32,520 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCND3

Protein Structure Not Found.


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Sites Implicated In
protein degradation: T283‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T9‑p ELLCCEGtRHAPRAG
0 1 S254 IEAALRESLREASQt
0 1 T261‑p SLREASQtSssPAPK
0 1 S263‑p REASQtSssPAPKAP
0 6 S264‑p EASQtSssPAPKAPR
0 2 S274‑p PKAPRGSsSQGPsQt
0 7 S279‑p GSsSQGPsQtstPtD
0 1 T281‑p sSQGPsQtstPtDVt
0 1 S282‑p SQGPsQtstPtDVtA
6 8 T283‑p QGPsQtstPtDVtAI
0 1 T285‑p PsQtstPtDVtAIHL
0 1 T288‑p tstPtDVtAIHL___
  CCND3 iso2  
- gap
S173 IEAALRESLREASQT
T180 SLREASQTSSSPAPK
S182 REASQTSSSPAPKAP
S183 EASQTSSSPAPKAPR
S193 PKAPRGSSSQGPSQT
S198 GSSSQGPSQTSTPTD
T200 SSQGPSQTSTPTDVT
S201 SQGPSQTSTPTDVTA
T202 QGPSQTSTPTDVTAI
T204 PSQTSTPTDVTAIHL
T207 TSTPTDVTAIHL___
  CCND3 iso3  
T9 ELLCCEGTRHAPRAG
S182 IEAALRESLREASQT
T189 SLREASQTSSSPAPK
S191 REASQTSSSPAPKAP
S192 EASQTSSSPAPKAPR
S202 PKAPRGSSSQGPSQT
S207 GSSSQGPSQTSTPTD
T209 SSQGPSQTSTPTDVT
S210 SQGPSQTSTPTDVTA
T211 QGPSQTSTPTDVTAI
T213 PSQTSTPTDVTAIHL
T216 TSTPTDVTAIHL___
  CCND3 iso4  
- gap
S58 IEAALRESLREASQT
T65 SLREASQTSSSPAPK
S67 REASQTSSSPAPKAP
S68 EASQTSSSPAPKAPR
S78 PKAPRGSSSQGPSQT
S83 GSSSQGPSQTSTPTD
T85 SSQGPSQTSTPTDVT
S86 SQGPSQTSTPTDVTA
T87 QGPSQTSTPTDVTAI
T89 PSQTSTPTDVTAIHL
T92 TSTPTDVTAIHL___
  mouse

 
T9 ELLCCEGTRHAPRAG
S254‑p IEAALREsLREAAQT
T261 sLREAAQTAPsPVPK
P263 REAAQTAPsPVPKAP
S264‑p EAAQTAPsPVPKAPR
S274‑p PKAPRGSsSQGPSQT
S279 GSsSQGPSQTStPTD
T281 sSQGPSQTStPTDVT
S282 SQGPSQTStPTDVTA
T283‑p QGPSQTStPTDVTAI
T285 PSQTStPTDVTAIHL
T288 TStPTDVTAIHL___
  rat

 
T9 ELLCCEGTRLAPRAG
S255 IEAALRESLREAAQT
T262 SLREAAQTAPsPVPK
P264 REAAQTAPsPVPKAP
S265‑p EAAQTAPsPVPKAPG
S275 PKAPGGSSSQGPSQT
S280 GSSSQGPSQTSTPTD
T282 SSQGPSQTSTPTDVT
S283 SQGPSQTSTPTDVTA
T284 QGPSQTSTPTDVTAI
T286 PSQTSTPTDVTAIHL
T289 TSTPTDVTAIHL___
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