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Protein Page:
CASP6 (human)

CASP6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of Human Ortholog: 4q25
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; identical protein binding; protein binding
Biological Process: apoptosis; cell structure disassembly during apoptosis; epithelial cell differentiation; proteolysis; regulation of apoptosis
Reference #:  P55212 (UniProtKB)
Alt. Names/Synonyms: Apoptotic protease Mch-2; CASP-6; CASP6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; MCH2
Gene Symbols: CASP6
Molecular weight: 33,310 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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