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Protein Page:
Tyk2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Tyk2 a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; EC 2.7.10.2; TK group; JakA family
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus
Molecular Function: growth hormone receptor binding; protein binding; protein-tyrosine kinase activity
Biological Process: cell differentiation; cell migration; innate immune response; protein amino acid phosphorylation; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Immunodeficiency 35
Reference #:  P29597 (UniProtKB)
Alt. Names/Synonyms: JTK1; Non-receptor tyrosine-protein kinase TYK2; TYK2; tyrosine kinase 2
Gene Symbols: TYK2
Molecular weight: 133,650 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Tyk2

Protein Structure Not Found.
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Sites Implicated In
enzymatic activity, induced: Y1054‑p, Y1055‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T67‑p IAHKVGItPPCFNLF
1 1465 Y292‑p QAEGEPCyIRDSGVA
0 1 S339‑p EVNKEEGssGSSGRN
0 1 S340‑p VNKEEGssGSSGRNP
0 1 Y423‑p FVSLVDGyFRLTADS
0 34 Y433‑p LTADSSHyLCHEVAP
0 1 S491‑p ILTVAQRsQAPDGMQ
0 9 S499‑p QAPDGMQsLRLRKFP
0 3 S525 GWGRSFPSVRELGAA
0 2 S577‑p SPRTLNLsQLSFHRV
0 1 Y604 QGTRTNVYEGRLRVE
0 1 S720‑p VVAQQLAsALsYLEN
0 2 S723‑p QQLAsALsYLENKNL
0 1 K728 ALsYLENKNLVHGNV
0 4 K756‑ub EGTSPFIkLSDPGVG
0 32 Y827‑p PSEKEHFyQRQHRLP
0 1 Y851‑p LTSQCLTyEPTQRPS
0 3 S884‑p VLTVNPDsPASDPTV
0 1 Y914 HFGKVSLYCYDPTND
0 1 S942 DCGPQHRSGWKQEID
6 60 Y1054‑p AVPEGHEyyRVREDG
5 7 Y1055‑p VPEGHEyyRVREDGD
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
68790 : Phospho-Tyk2 (Tyr1054/1055) (D7T8A) Rabbit mAb
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
68790 : Phospho-Tyk2 (Tyr1054/1055) (D7T8A) Rabbit mAb
  mouse

 
T68 IAHKVGITPPCLNLF
Y291‑p QPERDPCyIQNSGQT
- gap
- gap
Y418 FVALVDGYFRLTADS
Y428‑p LTADSSHyLCHEVAP
N486 ILTVAHRNPAXSNGP
G495 AXSNGPRGLRLRKFP
S521‑p GWGRSFAsLGDLRLA
S573 HTRPLNLSQLSFHRV
Y600‑p QGTRTNVyEGLLRVG
S713 VVAQQLASALSYLED
S716 QQLASALSYLEDkNL
K721‑ac ALSYLEDkNLVHGNV
K749‑ub EGTNPFIkLSDPGVG
Y820 PSEKERFYTKKHQLP
Y844 LTRQCLTYEPAQRPS
S877 TSAVNSDSPASDPTV
Y907‑p HFGKVSLyCYDPTND
S935‑p GCGPQLRsGWQREIE
Y1047‑p AVPEGHEyyRVREDG
Y1048‑p VPEGHEyyRVREDGD
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
68790 : Phospho-Tyk2 (Tyr1054/1055) (D7T8A) Rabbit mAb
9321 : Phospho-Tyk2 (Tyr1054/1055) Antibody
68790 : Phospho-Tyk2 (Tyr1054/1055) (D7T8A) Rabbit mAb
  rat

 
T72 IAHKVGITPPCLNLF
Y297 QPERDPCYIQNSGQT
- gap
- gap
Y424 FVALVDGYFRLTADS
Y434 LTADSSHYLCHEVAP
N492 ILTVAHRNPASRNGP
G501 ASRNGPRGLRLRKFP
S527 GWGRSFDSLGDLRQA
S579 HTRPLNLSQLSFHRV
Y606 QGTRTNVYEGLLSVG
S719 VVAQQLASALSYLED
S722 QQLASALSYLEDKNL
K727 ALSYLEDKNLVHGNV
K755 EGTNPFIKLSDPGVG
Y826 PSEKERFYTKKHQLP
Y850 LTRQCLSYEPAQRPS
S883 TSTVNSDSPASDPTV
Y913 HFGKVSLYCYDPNND
S941 GCGPQLRSGWQREIE
Y1053 AVPEGHEYYRVREDG
Y1054 VPEGHEYYRVREDGD
68790 : Phospho-Tyk2 (Tyr1054/1055) (D7T8A) Rabbit mAb
68790 : Phospho-Tyk2 (Tyr1054/1055) (D7T8A) Rabbit mAb
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