GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs; Motility/polarity/chemotaxis; GAPs, Rac/Rho; Oncoprotein
Molecular Function: GTPase activator activity; phospholipid binding; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; nervous system development; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.