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Protein Page:
CCNE2 (human)

Overview
CCNE2 Essential for the control of the cell cycle at the late G1 and early S phase. Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively. According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. Belongs to the cyclin family. Cyclin E subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component: cytosol; nucleoplasm
Molecular Function: protein binding
Biological Process: cell cycle checkpoint; G1/S transition of mitotic cell cycle; regulation of cyclin-dependent protein kinase activity
Reference #:  O96020 (UniProtKB)
Alt. Names/Synonyms: CCNE2; CYCE2; cyclin E2; G1/S-specific cyclin E2; G1/S-specific cyclin-E2
Gene Symbols: CCNE2
Molecular weight: 46,757 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCNE2

Protein Structure Not Found.


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