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Protein Page:
mTOR (human)

mTOR an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779). Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Autophagy; EC; FRAP subfamily; Kinase, protein; Motility/polarity/chemotaxis; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 1p36.2
Cellular Component: cytoplasm; cytosol; endomembrane system; lysosomal membrane; lysosome; membrane; nucleoplasm; nucleus; PML body; TORC2 complex
Molecular Function: kinase activity; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: autophagy; cell cycle arrest; cell growth; cellular response to nutrient levels; DNA repair; macroautophagy; negative regulation of autophagy; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein catabolic process; regulation of actin cytoskeleton organization and biogenesis; regulation of osteoclast differentiation; response to amino acid stimulus; response to stress; T cell costimulation; TOR signaling pathway
Disease: Smith-kingsmore Syndrome
Reference #:  P42345 (UniProtKB)
Alt. Names/Synonyms: FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); mTOR; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin target protein 1; RAPT1; Serine/threonine-protein kinase mTOR
Gene Symbols: MTOR
Molecular weight: 288,892 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  Autophagy Signaling  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  IL6 Signaling  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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