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Protein Page:
mTOR (human)

Overview
mTOR an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779). Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; Autophagy; EC 2.7.11.1; FRAP subfamily; Kinase, protein; Motility/polarity/chemotaxis; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical
Chromosomal Location of Human Ortholog: 1p36.2
Cellular Component: cytoplasm; cytosol; endomembrane system; lysosomal membrane; lysosome; membrane; nucleoplasm; nucleus; PML body; TORC2 complex
Molecular Function: kinase activity; phosphoprotein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: autophagy; cell cycle arrest; cell growth; cellular response to nutrient levels; DNA repair; macroautophagy; negative regulation of autophagy; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; phosphorylation; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein catabolic process; regulation of actin cytoskeleton organization and biogenesis; regulation of osteoclast differentiation; response to amino acid stimulus; response to stress; T cell costimulation; TOR signaling pathway
Disease: Smith-kingsmore Syndrome
Reference #:  P42345 (UniProtKB)
Alt. Names/Synonyms: FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); mTOR; RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; Rapamycin target protein 1; RAPT1; Serine/threonine-protein kinase mTOR
Gene Symbols: MTOR
Molecular weight: 288,892 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  Autophagy Signaling  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  IL6 Signaling  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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mTOR

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