binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; protein complex
Molecular Function: eukaryotic initiation factor 4E binding; protein binding; protein phosphatase 2A binding; translation initiation factor binding; translation repressor activity
Biological Process: G1/S transition of mitotic cell cycle; insulin receptor signaling pathway; negative regulation of protein complex assembly; negative regulation of translational initiation; positive regulation of mitotic cell cycle; regulation of translational initiation; TOR signaling pathway
Alt. Names/Synonyms: 4E-BP1; 4EBP1; AA959816; eIF4E-binding protein 1; Eif4ebp1; eukaryotic translation initiation factor 4E binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1