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Protein Page:
THEMIS (human)

Overview
THEMIS Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Interacts with PLCG1, ITK and GRB2. Belongs to the themis family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 6q22.33
Cellular Component: cytoplasm; nucleus; signalosome
Molecular Function: protein binding
Biological Process: negative T cell selection; positive T cell selection; T cell receptor signaling pathway
Reference #:  Q8N1K5 (UniProtKB)
Alt. Names/Synonyms: bA325O24.3; bA325O24.4; C6orf190; C6orf207; FLJ40584; MGC163388; Protein THEMIS; THEMIS; THMS1; thymocyte selection associated; thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection; TSEPA
Gene Symbols: THEMIS
Molecular weight: 73,452 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

THEMIS

Protein Structure Not Found.


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