Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
RAP1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAP1B GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric, Ras; G protein; G protein, monomeric
Chromosomal Location of Human Ortholog: 12q14
Cellular Component: cytosol; intercellular junction; intracellular; lipid particle; lipid raft; membrane; plasma membrane
Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding; protein complex binding
Biological Process: microvillus biogenesis; Rap protein signal transduction
Reference #:  P61224 (UniProtKB)
Alt. Names/Synonyms: DKFZp586H0723; GTP-binding protein smg p21B; K-REV; RAL1B; RAP1B; RAP1B, member of RAS oncogene family; Ras family small GTP binding protein RAP1B; Ras-related protein Rap-1b; RAS-related protein RAP1B
Gene Symbols: RAP1B
Molecular weight: 20,825 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RAP1B

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
activity, induced: S179‑p
protein conformation: S179‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K5‑ub ___MREYkLVVLGsG
0 7 S11‑p YkLVVLGsGGVGKSA
0 57 K31‑ub VQGIFVEkYDPTIED
0 10 S39‑p YDPTIEDsyRKQVEV
0 3 Y40‑p DPTIEDsyRKQVEVD
0 1 T106 QILRVKDTDDVPMIL
0 1 K117 PMILVGNKCDLEDER
0 2 K128‑ub EDERVVGkEQGQNLA
0 1 K149 AFLESSAKSKINVNE
0 1 K151 LESSAKSKINVNEIF
0 77 Y159‑p INVNEIFyDLVRQIN
5 1 S179‑p PGKARKKsscQLL__
2 0 S180‑p GKARKKsscQLL___
1 0 C181‑me KARKKsscQLL____
  mouse

 
K5‑ub ___MREYkLVVLGSG
S11 YkLVVLGSGGVGKSA
K31‑ub VQGIFVEkYDPTIED
S39‑p YDPTIEDsYRKQVEV
Y40 DPTIEDsYRKQVEVD
T106‑p QILRVKDtDDVPMIL
K117‑ub PMILVGNkCDLEDER
K128‑ub EDERVVGkEQGQNLA
K149‑ub AFLESSAkSKINVNE
K151 LESSAkSKINVNEIF
Y159‑p INVNEIFyDLVRQIN
S179‑p PGKARKKsSCQLL__
S180 GKARKKsSCQLL___
C181 KARKKsSCQLL____
  rat

 
K5 ___MREYKLVVLGSG
S11 YKLVVLGSGGVGKSA
K31‑ub VQGIFVEkYDPTIED
S39 YDPTIEDSYRKQVEV
Y40 DPTIEDSYRKQVEVD
T106 QILRVKDTDDVPMIL
K117 PMILVGNKCDLEDER
K128 EDERVVGKEQGQNLA
K149 AFLESSAKSkINVNE
K151‑ac LESSAKSkINVNEIF
Y159‑p INVNEIFyDLVRQIN
S179 PGKARKKSSCQLL__
S180 GKARKKSSCQLL___
C181 KARKKSSCQLL____
  cow

 
K5 ___MREYKLVVLGSG
S11 YKLVVLGSGGVGKSA
K31 VQGIFVEKYDPTIED
S39 YDPTIEDSYRKQVEV
Y40 DPTIEDSYRKQVEVD
T106 QILRVKDTDDVPMIL
K117 PMILVGNKCDLEDER
K128 EDERVVGKEQGQNLA
K149 AFLESSAKSKINVNE
K151 LESSAKSKINVNEIF
Y159 INVNEIFYDLVRQIN
S179‑p PGKARKKssCQLL__
S180‑p GKARKKssCQLL___
C181 KARKKssCQLL____
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.