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Protein Page:
GAD67 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GAD67 Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; EC 4.1.1.15; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Carbohydrate Metabolism - butanoate; Lyase
Chromosomal Location of Human Ortholog: 2q31
Cellular Component: intracellular; plasma membrane; presynaptic active zone; vesicle membrane
Molecular Function: glutamate binding; glutamate decarboxylase activity; protein binding; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding
Biological Process: gamma-aminobutyric acid biosynthetic process; glutamate catabolic process; glutamate decarboxylation to succinate; neurotransmitter biosynthetic process; neurotransmitter secretion; protein-pyridoxal-5-phosphate linkage; response to drug; synaptic transmission
Disease: Cerebral Palsy, Spastic Quadriplegic, 1
Reference #:  Q99259 (UniProtKB)
Alt. Names/Synonyms: 67 kDa glutamic acid decarboxylase; DCE1; FLJ45882; GAD; GAD-67; GAD1; GAD67; Glutamate decarboxylase 1; glutamate decarboxylase 1 (brain, 67kDa); Glutamate decarboxylase 67 kDa isoform; SCP
Gene Symbols: GAD1
Molecular weight: 66,897 Da
Basal Isoelectric point: 7.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GAD67

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S56 GFLQRTNSLEEKSRL
0 1 K60 RTNSLEEKSRLVSAF
0 2 S72 SAFKERQSSKNLLSC
0 3 S73 AFKERQSSKNLLSCE
0 4 K74 FKERQSSKNLLSCEN
0 6 S78 QSSKNLLSCENSDRD
1 0 T91‑p RDARFRRtETDFSNL
0 1 K177 VDCRDTLKYGVRTGH
0 32 Y265‑p YSIMAARyKYFPEVK
0 1 K272 yKYFPEVKTKGMAAV
0 1 K471 FWLMWKAKGTVGFEN
0 1 Y489‑p KCLELAEyLyAKIKN
0 1 Y491‑p LELAEyLyAKIKNRE
0 1 S571‑p NFFRMVIsNPAATQs
0 1 S578‑p sNPAATQsDIDFLIE
  mouse

 
S55‑p GFLQRTNsLEEKSRL
K59 RTNsLEEKSRLVSAF
S71‑p SAFRERQssKNLLsC
S72‑p AFRERQssKNLLsCE
K73 FRERQssKNLLsCEN
S77‑p QssKNLLsCENSDQG
T90 QGARFRRTETDFSNL
K176 VDCRDTLKYGVRTGH
Y264 YSIMAARYKYFPEVK
K271 YKYFPEVKTKGMAAV
K470‑ub FWLMWKAkGTVGFEN
Y488 KCLELADYLYAKIKN
Y490 LELADYLYAKIKNRE
S570 NFFRMVISNPAATQS
S577 SNPAATQSDIDFLIE
  rat

 
S55‑p GFLQRTNsLEEkSRL
K59‑ub RTNsLEEkSRLVSAF
A71 SAFRERQASkNLLSC
S72 AFRERQASkNLLSCE
K73‑ub FRERQASkNLLSCEN
S77 QASkNLLSCENSDPG
T90 PGARFRRTETDFSNL
K176‑ac VDCRDTLkYGVRTGH
Y264‑p YSIMAARyKYFPEVk
K271‑ac yKYFPEVkTKGMAAV
K470 FWLMWKAKGTVGFEN
Y488 KCLELAEYLYAKIKN
Y490 LELAEYLYAKIKNRE
S570 NFFRMVISNPAATQS
S577 SNPAATQSDIDFLIE
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