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Protein Page:
ARPP-19 (human)

ARPP-19 a protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at S62 by MASTL during mitosis, specifically interacts with PPP2R2D and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP43 expression. Interacts with SNCA. Two isoforms of the human protein, ARPP-19 and ARPP-16, are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 15q21.2
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: phosphatase inhibitor activity; potassium channel regulator activity; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase type 2A regulator activity; receptor binding
Biological Process: G2/M transition of mitotic cell cycle; mitosis; negative regulation of protein amino acid dephosphorylation; positive regulation of gluconeogenesis
Reference #:  P56211 (UniProtKB)
Alt. Names/Synonyms: ARP19; ARPP-16; ARPP-19; ARPP16; ARPP19; cAMP-regulated phosphoprotein 19; cAMP-regulated phosphoprotein, 19kDa; cyclic AMP phosphoprotein, 19 kD; endosulfine alpha-like; ENSAL; FLJ41622
Gene Symbols: ARPP19
Molecular weight: 12,323 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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