a protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Specifically interacts with PPP2R2D (PR55-delta) during mitosis and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. May be associated with type 2 diabetes. Nine alternatively spliced human isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Molecular Function: ion channel inhibitor activity; phosphatase inhibitor activity; potassium channel inhibitor activity; protein binding; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity; receptor binding
Biological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of protein amino acid dephosphorylation; regulation of insulin secretion; response to nutrient; transport