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Protein Page:
ENSA (human)

ENSA a cytoplasmic, highly conserved cAMP-regulated phosphoprotein (ARPP) and regulator of ATP-sensitive potassium (KATP) channels. An endogenous ligand for the sulfonylurea receptor, ABCC8, the regulatory subunit of the KATP channel located on the plasma membrane of pancreatic beta cells. Modulates insulin secretion through the interaction with ABCC8, and may be associated with type 2 diabetes. Eight alternatively spliced isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytoplasm; nucleoplasm
Molecular Function: ion channel inhibitor activity; phosphatase inhibitor activity; potassium channel inhibitor activity; protein binding; protein phosphatase 2A binding; protein phosphatase inhibitor activity; protein phosphatase regulator activity; receptor binding
Biological Process: G2/M transition of mitotic cell cycle; mitosis; negative regulation of protein amino acid dephosphorylation; regulation of insulin secretion; response to nutrient; transport
Reference #:  O43768 (UniProtKB)
Alt. Names/Synonyms: Alpha-endosulfine; ARPP-19e; endosulfine alpha; ENSA; MGC4319; MGC78563; MGC8394
Gene Symbols: ENSA
Molecular weight: 13,389 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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