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Protein Page:
TPH1 (human)

Overview
TPH1 an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.16.4; Amino Acid Metabolism - tryptophan; Oxidoreductase
Chromosomal Location of Human Ortholog: 11p15.3-p14
Cellular Component: cytosol; neuron projection
Molecular Function: amino acid binding; iron ion binding; tryptophan 5-monooxygenase activity
Biological Process: aromatic amino acid family metabolic process; bone remodeling; circadian rhythm; indolalkylamine biosynthetic process; negative regulation of ossification; positive regulation of fat cell differentiation; serotonin biosynthetic process
Reference #:  P17752 (UniProtKB)
Alt. Names/Synonyms: indoleacetic acid-5-hydroxylase; L-tryptophan hydroxylase; MGC119994; TPH; TPH1; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; tryptophan hydroxylase (tryptophan 5-monooxygenase); tryptophan hydroxylase 1
Gene Symbols: TPH1
Molecular weight: 50,985 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TPH1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
4 0 S58‑p RKSKRRNsEFEIFVD
0 1 T225‑p SNFLKERtGFsIRPV
0 1 S228‑p LKERtGFsIRPVAGY
0 1 S243 LSPRDFLSGLAFRVF
1 0 S260‑p TQYVRHSsDPFYTPE
0 1 Y373‑p ITTFQDVyFVSESFE
0 1 Y401‑p KRPFGVKyNPyTRSI
0 1 Y404‑p FGVKyNPyTRSIQIL
0 1 S407 KyNPyTRSIQILKDT
  mouse

 
S61 RKSKQRNSEFEIFVD
T228 SNFLKERTGFSIRPV
S231 LKERTGFSIRPVAGY
S246‑p LSPRDFLsGLAFRVF
S263 TQYVRHSSDPLYTPE
Y376 ITSFQDVYFVSESFE
Y404 KRPFGLKYNPYTQsV
Y407 FGLKYNPYTQsVQVL
S410‑p KYNPYTQsVQVLRDT
  rat

 
S58‑p RKSKRRNsEFEIFVD
T225 SNFLKERTGFSIRPV
S228 LKERTGFSIRPVAGY
S243 LSPRDFLSGLAFRVF
S260 TQYVRHSSDPLYTPE
Y373 ITSFQDVYFVSESFE
Y401 KRPFGVKYNPYTQSI
Y404 FGVKYNPYTQSIQVL
S407 KYNPYTQSIQVLRDS
  rabbit

 
S58‑p RKSKRRNsEFEIFVD
T225 SNFLKERTGFSIRPV
S228 LKERTGFSIRPVAGY
S243 LSPRDFLSGLAFRVF
S260 TQYVRHSSDPFYTPE
Y373 ITTFQDVYFVSESFE
Y401 KRPFGVKYNPYTRSI
Y404 FGVKYNPYTRSIQIL
S407 KYNPYTRSIQILKDA
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