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Protein Page:
COX-1 (human)

Overview
COX-1 May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.14.99.1
Chromosomal Location of Human Ortholog: 9q32-q33.3
Cellular Component: cytoplasm; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bound organelle; nuclear envelope; nucleus; photoreceptor outer segment
Molecular Function: dioxygenase activity; heme binding; lipid binding; metal ion binding; peroxidase activity; prostaglandin-endoperoxide synthase activity
Biological Process: aging; arachidonic acid metabolic process; cyclooxygenase pathway; inflammatory response; learning; lipid metabolic process; memory; negative regulation of epinephrine secretion; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction; prostaglandin biosynthetic process; regulation of blood pressure; regulation of cell proliferation; response to corticosterone stimulus; response to organic nitrogen; response to oxidative stress; sensory perception of pain; xenobiotic metabolic process
Reference #:  P23219 (UniProtKB)
Alt. Names/Synonyms: COX-1; COX1; cyclooxygenase-1; Cyclooxygenase-1; PCOX1; PGG/HS; PGH synthase 1; PGH1; PGHS-1; PGHS1; PHS 1; PHS1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGHS; PTGS1; RP11-542K23.6
Gene Symbols: PTGS1
Molecular weight: 68,686 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

COX-1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y54‑p VRFGLDRyQCDCTRT
0 2 T117‑p MLMRLVLtVRSNLIP
0 1 T220‑p GKMGPGFtKALGHGV
  mouse

 
Y57 VRFGLDNYQCDCTRT
T120 VLMRLVLTVRSNLIP
T223 GKMGPGFTKALGHGV
  sheep

 
Y55 VRFGLDRYQCDCTRT
T118 TLMRLVLTVRSNLIP
T221 GKMGPGFTKALGHGV
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