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Protein Page:
PUMA (mouse)

Overview
PUMA Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial
Cellular Component: lysosome; mitochondrial envelope; mitochondrion
Molecular Function: ATPase binding; glycoprotein binding; protein binding
Biological Process: apoptosis; caspase activation; determination of adult life span; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of cell growth; negative regulation of growth; positive regulation of apoptosis; positive regulation of neuron apoptosis; positive regulation of protein homooligomerization; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria; release of sequestered calcium ion into cytosol; response to DNA damage stimulus
Reference #:  Q99ML1 (UniProtKB)
Alt. Names/Synonyms: Bbc3; Bcl-2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; BH3-only; OTTMUSP00000025190; p53 up-regulated modulator of apoptosis; Puma; PUMA/JFY1
Gene Symbols: Bbc3
Molecular weight: 20,749 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PUMA

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
2 7 S10‑p RARQEGSsPEPVEGL
0 1 S21‑p VEGLARDsPRPFPLG
1 0 Y58 PALLPAAYLCAPTAP
1 0 S96 RPDGPQPSLSPAQQH
1 0 S106 PAQQHLESPVPSAPE
1 0 Y152 ADDLNAQYERRRQEE
0 1 S166 EQHRHRPSPWRVMYN
1 1 Y172 PSPWRVMYNLFMGLL
  human

 
S10‑p RARQEGSsPEPVEGL
G21 VEGLARDGPRPFPLG
Y58‑p PTLLPAAyLCAPTAP
S96‑p RPDGPQPsLSLAEQH
S106‑p LAEQHLEsPVPSAPG
Y152‑p ADDLNAQyERRRQEE
S166‑p EQQRHRPsPWRVLyN
Y172‑p PsPWRVLyNLIMGLL
  rat

 
S10 RARQEGSSPEPVEGL
S21 VEGLARDSPRPFPLG
Y58 PALLPAAYLCAPTAP
S96 RPDGPQPSLSPAQQH
S106 PAQQHLESPVPSAPE
Y152 ADDLNAQYERRRQEE
S166 EQHRHRPSPWRVMYN
Y172 PSPWRVMYNLFMGLL
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