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Protein Page:
PUMA (mouse)

Overview
PUMA essential mediator of p53-dependent and independent apoptosis. Binds to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Interacts with BCL2, BCL2L1, MCL1 and BCL2A1. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53. Regulates ER stress-induced neuronal apoptosis. Induced by DNA damage, glucocorticoid treatment, growth factor deprivation and p53. Ubiquitously expressed. Ubiquitously expressed. Belongs to the Bcl-2 family, BH3-only pro-apoptotic subclass. Four isoforms of the human protein are apparently produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Mitochondrial
Cellular Component: lysosome; mitochondrial envelope; mitochondrion
Molecular Function: ATPase binding; glycoprotein binding
Biological Process: apoptosis; caspase activation; determination of adult life span; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of cell growth; negative regulation of growth; positive regulation of apoptosis; positive regulation of neuron apoptosis; positive regulation of protein homooligomerization; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria; release of sequestered calcium ion into cytosol; response to DNA damage stimulus
Reference #:  Q99ML1 (UniProtKB)
Alt. Names/Synonyms: Bbc3; Bcl-2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; BH3-only; OTTMUSP00000025190; p53 up-regulated modulator of apoptosis; Puma; PUMA/JFY1
Gene Symbols: Bbc3
Molecular weight: 20,749 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PUMA

Protein Structure Not Found.
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