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Protein Page:
IL1A (human)

Overview
IL1A Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytokine
Chromosomal Location of Human Ortholog: 2q14
Cellular Component: cytosol; extracellular region; extracellular space
Molecular Function: copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding
Biological Process: apoptosis; cell proliferation; connective tissue replacement during inflammatory response; cytokine and chemokine mediated signaling pathway; fever; germ cell programmed cell death; immune response; inflammatory response; negative regulation of cell proliferation; positive regulation of angiogenesis; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 biosynthetic process; positive regulation of JNK cascade; positive regulation of mitosis; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; response to copper ion
Reference #:  P01583 (UniProtKB)
Alt. Names/Synonyms: Hematopoietin-1; IL-1 alpha; IL-1A; IL1; IL1-ALPHA; IL1A; IL1F1; interleukin 1, alpha; Interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha
Gene Symbols: IL1A
Molecular weight: 30,607 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Select Structure to View Below

IL1A

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S16‑p EDLKNCYsENEEDSS
0 1 S22 YsENEEDSSSIDHLS
0 1 T59‑p VSLSISEtsKTSKLt
0 1 S60‑p SLSISEtsKTSKLtF
0 1 T66‑p tsKTSKLtFKESMVV
1 1 S87‑p VLKKRRLsLSQSITD
0 1 S104‑p LEAIANDsEEEIIKP
0 1 S113 EEIIKPRSAPFSFLS
0 1 T189‑p VILRISKtQLYVTAQ
  mouse

 
S16‑p EDLKNCYsENEDYsS
S22‑p YsENEDYsSAIDHLS
T59 VSLRTSETSKMSNFT
S60 SLRTSETSKMSNFTF
T66 TSKMSNFTFKESRVT
S90‑p ILKKRRLsFSETFTE
L107 LQSITHDLEETIQPR
S115‑p EETIQPRsAPYTYQS
S192 VTLKISDSQLFVSAQ
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