Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytokine
Cellular Component: cytosol; extracellular region; extracellular space
Molecular Function: copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding
Biological Process: apoptosis; cell proliferation; connective tissue replacement during inflammatory response; cytokine and chemokine mediated signaling pathway; fever; germ cell programmed cell death; inflammatory response; inflammatory response to antigenic stimulus; negative regulation of cell proliferation; positive regulation of angiogenesis; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 biosynthetic process; positive regulation of JNK cascade; positive regulation of mitosis; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; response to copper ion
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.