Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
IL28A (human)

IL28A Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular region; extracellular space
Molecular Function: receptor binding
Biological Process: defense response to virus; innate immune response; mucosal immune response; regulation of T cell activation
Reference #:  Q8IZJ0 (UniProtKB)
Alt. Names/Synonyms: Cytokine Zcyto20; IFN-lambda-2; IFNL2; IL-28A; IL28A; interferon lambda 2; Interferon lambda-2; interferon-lambda 2; interleukin 28A (interferon, lambda 2); Interleukin-28A; ZCYTO20
Gene Symbols: IFNL2
Molecular weight: 22,288 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene