Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. Belongs to the OS-9 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: carbohydrate binding; glycoprotein binding; protease binding; protein binding
Biological Process: cellular protein metabolic process; ER-associated protein catabolic process; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein folding; protein retention in ER; protein targeting; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; retrograde protein transport, ER to cytosol
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.