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Protein Page:
PIR (human)

Overview
PIR Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA. Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract. Highly expressed in a subset of melanomas. Detected at very low levels in most tissues. Expressed in all tissues, with highest level of expression in heart and liver. Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. Belongs to the pirin family. Note: This description may include information from UniProtKB.
Protein type: EC 1.13.11.24; Oxidoreductase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: cytoplasm; nucleus
Molecular Function: metal ion binding; protein binding; quercetin 2,3-dioxygenase activity; transcription cofactor activity
Biological Process: monocyte differentiation; transcription from RNA polymerase II promoter
Reference #:  O00625 (UniProtKB)
Alt. Names/Synonyms: PIR; Pirin; pirin (iron-binding nuclear protein)
Gene Symbols: PIR
Molecular weight: 32,113 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PIR

Protein Structure Not Found.
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