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Protein Page:
TNFRSF6B (human)

Overview
TNFRSF6B Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q13.3
Cellular Component: extracellular region; integral to plasma membrane
Molecular Function: protein binding; receptor activity; tumor necrosis factor receptor activity
Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of apoptosis; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway
Reference #:  O95407 (UniProtKB)
Alt. Names/Synonyms: DCR3; Decoy receptor 3; Decoy receptor for Fas ligand; DJ583P15.1.1; M68; TNF6B; TNFRSF6B; TR6; Tumor necrosis factor receptor superfamily member 6B; tumor necrosis factor receptor superfamily, member 6b, decoy
Gene Symbols: TNFRSF6B
Molecular weight: 32,680 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TNFRSF6B

Protein Structure Not Found.
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