Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
ENDOG (human)

Overview
ENDOG Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. Homodimer. Belongs to the DNA/RNA non-specific endonuclease family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Deoxyribonuclease; EC 3.1.30.-; Mitochondrial; Ribonuclease
Chromosomal Location of Human Ortholog: 9q34.1
Molecular Function: protein binding
Biological Process: DNA fragmentation during apoptosis; DNA recombination
Reference #:  Q14249 (UniProtKB)
Alt. Names/Synonyms: Endo G; ENDOG; endonuclease G; Endonuclease G, mitochondrial; FLJ27463; NUCG
Gene Symbols: ENDOG
Molecular weight: 32,620 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ENDOG

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene