Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
PTCH2 (human)

PTCH2 May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). Belongs to the patched family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p34.1
Molecular Function: hedgehog receptor activity; smoothened binding
Biological Process: negative regulation of smoothened signaling pathway
Disease: Basal Cell Carcinoma, Susceptibility To, 1; Basal Cell Nevus Syndrome; Medulloblastoma
Reference #:  Q9Y6C5 (UniProtKB)
Alt. Names/Synonyms: patched homolog 2 (Drosophila); Protein patched homolog 2; PTC2; PTCH2
Gene Symbols: PTCH2
Molecular weight: 130,544 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene