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Protein Page:
EPCAM (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EPCAM a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; integral to plasma membrane; lateral plasma membrane; plasma membrane; tight junction
Molecular Function: protein binding; protein complex binding
Biological Process: negative regulation of apoptosis; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation; ureteric bud development
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 8; Diarrhea 5, With Tufting Enteropathy, Congenital
Reference #:  P16422 (UniProtKB)
Gene Symbols: EPCAM
Molecular weight: 34,932 Da
Basal Isoelectric point: 7.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EPCAM

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K168‑ub SLRTALQkEIttRYQ
0 1 T171‑ga TALQkEIttRYQLDP
0 1 T172‑ga ALQkEIttRYQLDPK
0 1 K179 tRYQLDPKFITSILY
0 1 Y214‑p VDIADVAyyFEkDVK
0 1 Y215‑p DIADVAyyFEkDVKG
0 1 K218‑ub DVAyyFEkDVKGESL
0 1 Y297‑p RKKRMAKyEkAEIkE
0 6 K299‑ub KRMAKyEkAEIkEMG
0 11 K303‑ub KyEkAEIkEMGEMHR
  mouse

 
E168 SLQTALQEAFTSRYK
T171 TALQEAFTSRYKLNQ
S172 ALQEAFTSRYKLNQK
K179 SRYKLNQKFIKNIMY
Y214 VDIADVAYYFEKDVK
Y215 DIADVAYYFEKDVKG
K218 DVAYYFEKDVKGESL
Y298 TRKKSAKYEKAEIkE
K300 KKSAKYEKAEIkEMG
K304‑ub KYEKAEIkEMGEIHR
  rat

 
D168 SLHTALQDTFASRYM
A171 TALQDTFASRYMLNP
S172 ALQDTFASRYMLNPk
K179‑ac SRYMLNPkFIKSIMY
Y214 VDIADVAYYFEKDVK
Y215 DIADVAYYFEKDVKG
K218 DVAYYFEKDVKGESL
Y298 TRKRSAKYEKAEIKE
K300 KRSAKYEKAEIKEMG
K304 KYEKAEIKEMGEIHR
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