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Protein Page:
EPCAM (human)

Overview
EPCAM a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: apical plasma membrane; basolateral plasma membrane; integral to plasma membrane; lateral plasma membrane; plasma membrane; tight junction
Molecular Function: protein binding; protein complex binding
Biological Process: positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 8; Diarrhea 5, With Tufting Enteropathy, Congenital
Reference #:  P16422 (UniProtKB)
Alt. Names/Synonyms: ACSTD1; Adenocarcinoma-associated antigen; carcinoma-associated antigen GA733-2; Cell surface glycoprotein Trop-1; CO-17A; CO17-1A; DIAR5; EGP; EGP-2; EGP314; EGP34; EGP40; Ep-CAM; EPCAM; Epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; hEGP-2; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; M1S2; M4S1; Major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; TACST-1; TACSTD1; TROP1; Tumor-associated calcium signal transducer 1
Gene Symbols: EPCAM
Molecular weight: 34,932 Da
Basal Isoelectric point: 7.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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EPCAM

Protein Structure Not Found.
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