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Protein Page:
LIF (human)

LIF LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: cytoplasm; extracellular region; extracellular space
Molecular Function: cytokine activity; growth factor activity; leukemia inhibitory factor receptor binding; receptor binding
Biological Process: alveolus development; astrocyte differentiation; blood vessel remodeling; decidualization; embryo implantation; immune response; leukemia inhibitory factor signaling pathway; multicellular organismal development; muscle morphogenesis; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of hormone secretion; negative regulation of meiosis; neuron development; organ regeneration; positive regulation of adrenocorticotropic hormone secretion; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of macrophage differentiation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; retina development in camera-type eye; stem cell differentiation; stem cell maintenance; tyrosine phosphorylation of Stat3 protein
Reference #:  P15018 (UniProtKB)
Alt. Names/Synonyms: CDF; cholinergic differentiation factor; D factor; DIA; differentiation inhibitory activity; differentiation stimulating factor; Differentiation-stimulating factor; HILDA; Leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI
Gene Symbols: LIF
Molecular weight: 22,008 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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