a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; GEFs; GEFs, Ras
Cellular Component: cell soma; cytosol; plasma membrane; postsynaptic density
Molecular Function: DNA binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process: axon guidance; B cell homeostasis; blood vessel morphogenesis; epidermal growth factor receptor signaling pathway; hair follicle development; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; multicellular organism growth; nerve growth factor receptor signaling pathway; palate development; positive regulation of apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of small GTPase mediated signal transduction; Ras protein signal transduction; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; regulation of T cell differentiation in the thymus; regulation of T cell proliferation; signal transduction; vitellogenesis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.