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Protein Page:
PTP-PEST (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTP-PEST Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Interacts with TGFB1I1. Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytoplasm; plasma membrane
Molecular Function: non-membrane spanning protein tyrosine phosphatase activity; protein binding; SH3 domain binding
Biological Process: protein amino acid dephosphorylation
Reference #:  Q05209 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTN12; PTPG1; PTPN12; Tyrosine-protein phosphatase non-receptor type 12
Gene Symbols: PTPN12
Molecular weight: 88,106 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTP-PEST

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
carcinogenesis, induced: S571‑p
cell motility, induced: S571‑p
activity, inhibited: S39‑p
molecular association, regulation: S571‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 11 S19‑p QRVQAMKsPDHNGED
3 15 S39‑p FMRLRRLstKYRTEK
0 3 T40‑p MRLRRLstKYRTEKI
0 7 Y64‑p ENVKKNRyKDILPFD
0 1 S83‑p KLTLKTPsQDSDyIN
0 4 Y88‑p TPsQDSDyINANFIK
0 1 S186 LLEFQNESRRLYQFH
0 1 K296 AIAQLFEKQLQLyEI
0 2 Y301‑p FEKQLQLyEIHGAQK
0 1 T318‑p DGVNEINtENMVssI
0 1 N320 VNEINtENMVssIEP
0 3 S323‑p INtENMVssIEPEKQ
0 2 S324‑p NtENMVssIEPEKQD
0 3 P327 NMVssIEPEKQDsPP
0 23 S332‑p IEPEKQDsPPPKPPR
0 2 S342‑p PKPPRTRsCLVEGDA
0 2 S369‑p VPPILTPsPPSAFPT
0 6 S397‑p KPVLHMVssEQHsAD
0 2 S398‑p PVLHMVssEQHsADL
0 1 S402‑p MVssEQHsADLNRNY
0 1 N408 HsADLNRNYSKSTEL
2 84 S435‑p KKLERNLsFEIKKVP
0 24 S449‑p PLQEGPKsFDGNtLL
0 2 T454‑p PKsFDGNtLLNRGHA
0 1 S466‑p GHAIKIKsAsPCIAD
0 5 S468‑p AIKIKsAsPCIADKI
0 1 T490‑p SDLNVGDtsQNsCVD
0 1 S491‑p DLNVGDtsQNsCVDC
0 1 S494‑p VGDtsQNsCVDCSVT
0 1 S507‑p VTQSNKVsVtPPEEs
0 18 T509‑p QSNKVsVtPPEEsQN
0 10 S514‑p sVtPPEEsQNsDtPP
0 9 S517‑p PPEEsQNsDtPPRPD
0 18 T519‑p EEsQNsDtPPRPDRL
0 14 L550 NAIPIPDLSEGNSSD
0 4 S555 PDLSEGNSSDINYQT
0 1 Y560 GNSSDINYQTRKtVs
0 1 T565‑p INYQTRKtVsLtPsP
0 3 S567‑p YQTRKtVsLtPsPtT
0 7 T569‑p TRKtVsLtPsPtTQV
1 11 S571‑p KtVsLtPsPtTQVEt
0 1 T573‑p VsLtPsPtTQVEtPD
0 3 T578‑p sPtTQVEtPDLVDHD
0 7 S588‑p LVDHDNTsPLFRtPL
0 1 T593‑p NTsPLFRtPLsFTNP
0 3 S596‑p PLFRtPLsFTNPLHs
0 2 T598 FRtPLsFTNPLHsDD
0 31 S603‑p sFTNPLHsDDsDsDE
0 30 S606‑p NPLHsDDsDsDERNs
0 15 S608‑p LHsDDsDsDERNsDG
0 1 N612 DsDsDERNsDGAVTQ
0 3 S613‑p sDsDERNsDGAVTQN
0 1 T622‑p GAVTQNKtNISTASA
0 1 S625 TQNKtNISTASATVS
0 1 T626 QNKtNISTASATVSA
0 1 T630 NISTASATVSAATST
0 1 S632 STASATVSAATSTES
0 1 T642 TSTESISTRKVLPMs
0 1 S649‑p TRKVLPMsIARHNIA
0 1 S661 NIAGTTHSGAEKDVD
0 8 S670‑p AEKDVDVsEDsPPPL
0 39 S673‑p DVDVsEDsPPPLPER
0 1 T681‑p PPPLPERtPESFVLA
0 6 S689‑p PESFVLAsEHNtPVR
0 7 T693‑p VLAsEHNtPVRSEWS
0 1 S708‑p ELQSQERsEQKKsEG
0 1 S713‑p ERsEQKKsEGLITsE
0 2 S719‑p KsEGLITsENEKCDH
0 1 Y733‑p HPAGGIHyEMCIECP
0 2 C736 GGIHyEMCIECPPTF
0 4 C739 HyEMCIECPPTFSDK
0 1 S751 SDKREQISENPTEAT
0 12 N753 KREQISENPTEATDI
0 1 T758 SENPTEATDIGFGNR
0 2 T780‑p RDPPSEWt_______
  PTP-PEST iso2  
- gap
- gap
- gap
- gap
- gap
- gap
S56 LLEFQNESRRLYQFH
K166 AIAQLFEKQLQLYEI
Y171 FEKQLQLYEIHGAQK
T188 DGVNEINTENMVSSI
N190 VNEINTENMVSSIEP
S193 INTENMVSSIEPEKQ
S194 NTENMVSSIEPEKQD
P197 NMVSSIEPEKQDSPP
S202 IEPEKQDSPPPKPPR
S212 PKPPRTRSCLVEGDA
S239 VPPILTPSPPSAFPT
S267 KPVLHMVSSEQHSAD
S268 PVLHMVSSEQHSADL
S272 MVSSEQHSADLNRNY
N278 HSADLNRNYSKSTEL
S305 KKLERNLSFEIKKVP
S319 PLQEGPKSFDGNTLL
T324 PKSFDGNTLLNRGHA
S336 GHAIKIKSASPCIAD
S338 AIKIKSASPCIADKI
T360 SDLNVGDTSQNSCVD
S361 DLNVGDTSQNSCVDC
S364 VGDTSQNSCVDCSVT
S377 VTQSNKVSVTPPEES
T379 QSNKVSVTPPEESQN
S384 SVTPPEESQNSDTPP
S387 PPEESQNSDTPPRPD
T389 EESQNSDTPPRPDRL
L420 NAIPIPDLSEGNSSD
S425 PDLSEGNSSDINYQT
Y430 GNSSDINYQTRKTVS
T435 INYQTRKTVSLTPSP
S437 YQTRKTVSLTPSPTT
T439 TRKTVSLTPSPTTQV
S441 KTVSLTPSPTTQVET
T443 VSLTPSPTTQVETPD
T448 SPTTQVETPDLVDHD
S458 LVDHDNTSPLFRTPL
T463 NTSPLFRTPLSFTNP
S466 PLFRTPLSFTNPLHS
T468 FRTPLSFTNPLHSDD
S473 SFTNPLHSDDSDSDE
S476 NPLHSDDSDSDERNS
S478 LHSDDSDSDERNSDG
N482 DSDSDERNSDGAVTQ
S483 SDSDERNSDGAVTQN
T492 GAVTQNKTNISTASA
S495 TQNKTNISTASATVS
T496 QNKTNISTASATVSA
T500 NISTASATVSAATST
S502 STASATVSAATSTES
T512 TSTESISTRKVLPMS
S519 TRKVLPMSIARHNIA
S531 NIAGTTHSGAEKDVD
S540 AEKDVDVSEDSPPPL
S543 DVDVSEDSPPPLPER
T551 PPPLPERTPESFVLA
S559 PESFVLASEHNTPVR
T563 VLASEHNTPVRSEWS
S578 ELQSQERSEQKKSEG
S583 ERSEQKKSEGLITSE
S589 KSEGLITSENEKCDH
Y603 HPAGGIHYEMCIECP
C606 GGIHYEMCIECPPTF
C609 HYEMCIECPPTFSDK
S621 SDKREQISENPTEAT
N623 KREQISENPTEATDI
T628 SENPTEATDIGFGNR
T650 RDPPSEWT_______
  PTP-PEST iso3  
- gap
- gap
- gap
- gap
- gap
- gap
S67 LLEFQNESRRLYQFH
K177 AIAQLFEKQLQLYEI
Y182 FEKQLQLYEIHGAQK
T199 DGVNEINTENMVSSI
N201 VNEINTENMVSSIEP
S204 INTENMVSSIEPEKQ
S205 NTENMVSSIEPEKQD
P208 NMVSSIEPEKQDSPP
S213 IEPEKQDSPPPKPPR
S223 PKPPRTRSCLVEGDA
S250 VPPILTPSPPSAFPT
S278 KPVLHMVSSEQHSAD
S279 PVLHMVSSEQHSADL
S283 MVSSEQHSADLNRNY
N289 HSADLNRNYSKSTEL
S316 KKLERNLSFEIKKVP
S330 PLQEGPKSFDGNTLL
T335 PKSFDGNTLLNRGHA
S347 GHAIKIKSASPCIAD
S349 AIKIKSASPCIADKI
T371 SDLNVGDTSQNSCVD
S372 DLNVGDTSQNSCVDC
S375 VGDTSQNSCVDCSVT
S388 VTQSNKVSVTPPEES
T390 QSNKVSVTPPEESQN
S395 SVTPPEESQNSDTPP
S398 PPEESQNSDTPPRPD
T400 EESQNSDTPPRPDRL
L431 NAIPIPDLSEGNSSD
S436 PDLSEGNSSDINYQT
Y441 GNSSDINYQTRKTVS
T446 INYQTRKTVSLTPSP
S448 YQTRKTVSLTPSPTT
T450 TRKTVSLTPSPTTQV
S452 KTVSLTPSPTTQVET
T454 VSLTPSPTTQVETPD
T459 SPTTQVETPDLVDHD
S469 LVDHDNTSPLFRTPL
T474 NTSPLFRTPLSFTNP
S477 PLFRTPLSFTNPLHS
T479 FRTPLSFTNPLHSDD
S484 SFTNPLHSDDSDSDE
S487 NPLHSDDSDSDERNS
S489 LHSDDSDSDERNSDG
N493 DSDSDERNSDGAVTQ
S494 SDSDERNSDGAVTQN
T503 GAVTQNKTNISTASA
S506 TQNKTNISTASATVS
T507 QNKTNISTASATVSA
T511 NISTASATVSAATST
S513 STASATVSAATSTES
T523 TSTESISTRKVLPMS
S530 TRKVLPMSIARHNIA
S542 NIAGTTHSGAEKDVD
S551 AEKDVDVSEDSPPPL
S554 DVDVSEDSPPPLPER
T562 PPPLPERTPESFVLA
S570 PESFVLASEHNTPVR
T574 VLASEHNTPVRSEWS
S589 ELQSQERSEQKKSEG
S594 ERSEQKKSEGLITSE
S600 KSEGLITSENEKCDH
Y614 HPAGGIHYEMCIECP
C617 GGIHYEMCIECPPTF
C620 HYEMCIECPPTFSDK
S632 SDKREQISENPTEAT
N634 KREQISENPTEATDI
T639 SENPTEATDIGFGNR
T661 RDPPSEWT_______
  mouse

 
S19‑p QRVQAMKsPDHNGED
S39‑p FMRLRRLsTKYRTEK
T40 MRLRRLsTKYRTEKI
Y64‑p ENVKKNRyKDILPFD
S83 KLTLKTPSQDSDYIN
Y88 TPSQDSDYINANFIK
S186‑p LLEFQNEsRRLYQFH
K296‑ub AIAQLFEkQLQLYEI
Y301 FEkQLQLYEIHGAQK
T317 ADGNEITTGtMVssI
T319‑p GNEITTGtMVssIDs
S322‑p ITTGtMVssIDsEKQ
S323‑p TTGtMVssIDsEKQD
S326‑p tMVssIDsEKQDsPP
S331‑p IDsEKQDsPPPKPPR
S341 PKPPRTRSCLVEGDA
S368‑p VPPILTPsPPSAFPT
S396‑p KPVLHMAsPEQHPAD
P397 PVLHMAsPEQHPADL
P401 MAsPEQHPADLNRsY
S407‑p HPADLNRsYDKSADP
S434‑p KKLERNLsFEIKKVP
S448‑p PLQEGPKsFDGNTLL
T453 PKsFDGNTLLNRGHA
S465 GHAIKIKSASSSVVD
S467 AIKIKSASSSVVDRT
V490 GALKVDDVSQNSCAD
S491 ALKVDDVSQNSCADC
S494 VDDVSQNSCADCSAA
- gap
S509 HSHRAAESSEESQSN
Q514 AESSEESQSNSHtPP
S517 SEESQSNSHtPPRPD
T519‑p ESQSNSHtPPRPDCL
S550‑p NATPVPDsPDGKsPD
S555‑p PDsPDGKsPDNHsQT
S560‑p GKsPDNHsQTLKTVS
T565 NHsQTLKTVSSTPNS
S567 sQTLKTVSSTPNSTA
T569 TLKTVSSTPNSTAEE
S572 TVSSTPNSTAEEEAH
T573 VSSTPNSTAEEEAHD
- gap
S588‑p LTEHHNSsPLLKAPL
A593 NSsPLLKAPLsFtNP
S596‑p PLLKAPLsFtNPLHs
T598‑p LKAPLsFtNPLHsDD
S603‑p sFtNPLHsDDsDsDG
S606‑p NPLHsDDsDsDGGss
S608‑p LHsDDsDsDGGssDG
S612‑p DsDsDGGssDGAVTR
S613‑p sDsDGGssDGAVTRN
T622 GAVTRNKTSIstASA
S625‑p TRNKTSIstASAtVs
T626‑p RNKTSIstASAtVsP
T630‑p SIstASAtVsPASSA
S632‑p stASAtVsPASSAES
T642‑p SSAESACtRRVLPMS
S649 tRRVLPMSIARQEVA
S661 EVAGTPHSGAEKDAD
S670‑p AEKDADVsEEsPPPL
S673‑p DADVsEEsPPPLPER
T681 PPPLPERTPESFVLA
- gap
M690 ESFVLADMPVRPEWH
S705 ELPNQEWSEQRESEG
S710 EWSEQRESEGLTTSG
S716 ESEGLTTSGNEKHDA
T728 HDAGGIHTEAsADsP
S731‑p GGIHTEAsADsPPAF
S734‑p HTEAsADsPPAFSDK
T746‑p SDKKDQItKsPAEVt
S748‑p KKDQItKsPAEVtDI
T753‑p tKsPAEVtDIGFGNR
T775 REPPSEWT_______
  rat

 
S19 QRVQAMKSPDHNGED
S39 FMRLRRLSTKYRTEK
T40 MRLRRLSTKYRTEKI
Y64 ENVKKNRYKDILPFD
S83 KLTLKTPSQDSDYIN
Y88 TPSQDSDYINANFIK
S186 LLEFQNESRRLYQFH
K296 AIAQLFEKQLQLYEI
Y301 FEKQLQLYEIHGAQK
T317 TDGNEISTGNMVSSI
N319 GNEISTGNMVSSIDS
S322 ISTGNMVSSIDSEKQ
S323 STGNMVSSIDSEKQD
S326 NMVSSIDSEKQDsPP
S331‑p IDSEKQDsPPPKPPR
S341 PKPPRTRSCLVEGDA
S368 VPPILTPSPPSAFPT
S396‑p KPVLHMAsPEQPPTD
P397 PVLHMAsPEQPPTDL
P401 MAsPEQPPTDLNRNY
N407 PPTDLNRNYDKSADL
S434‑p KKLEQNLsFEIKKVP
S448‑p PLQEGPKsFDGNTLL
T453 PKsFDGNTLLNRGHA
S465 GHAIKIKSASSSVVD
S467 AIKIKSASSSVVDKS
V490 GDLKVHDVSQNSCAD
S491 DLKVHDVSQNSCADC
S494 VHDVSQNSCADCSAS
- gap
S509 HLDNAPESSEESQNS
S513 APESSEESQNSHTPP
S516 SSEESQNSHTPPRPD
T518 EESQNSHTPPRPDCL
S549 NATPVSDSPDNHSQT
- gap
S554 SDSPDNHSQTLKTVS
T559 NHSQTLKTVSSTPNS
S561 SQTLKTVSSTPNSTA
T563 TLKTVSSTPNSTAEE
S566 TVSSTPNSTAEEESH
T567 VSSTPNSTAEEESHD
S572 NSTAEEESHDLTEHH
S582 LTEHHNSSPLPRAPL
A587 NSSPLPRAPLSFTNP
S590 PLPRAPLSFTNPLHs
T592 PRAPLSFTNPLHsDD
S597‑p SFTNPLHsDDsDsDE
S600‑p NPLHsDDsDsDEGNS
S602‑p LHsDDsDsDEGNSDG
N606 DsDsDEGNSDGAVTK
S607 sDsDEGNSDGAVTKN
T616 GAVTKNKTSISTASA
S619 TKNKTSISTASATVS
T620 KNKTSISTASATVSP
T624 SISTASATVSPASST
S626 STASATVSPASSTES
T636 SSTESACTRRVLPMS
S643 TRRVLPMSIARQEMA
S655‑p EMAGRRHsGAEKDAD
S664 AEKDADVSEEsPPPL
S667‑p DADVSEEsPPPLPER
T675 PPPLPERTPESFVLA
- gap
M684 ESFVLADMPIRSDWH
S699 ELPSQECSEHRESEG
S704 ECSEHRESEGLITSG
S710 ESEGLITSGNDKHDA
T722 HDAGVSHTAACSPTF
C725 GVSHTAACSPTFSDK
- gap
T737 SDKKEEITESLTEVT
S739 KKEEITESLTEVTDI
T744 TESLTEVTDIGFGNR
T766 RDPPSEWT_______
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