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Protein Page:
Stargazin (human)

Overview
Stargazin Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: plasma membrane
Molecular Function: calcium channel activity; channel regulator activity; protein binding
Biological Process: membrane depolarization; transmission of nerve impulse; transport
Disease: Mental Retardation, Autosomal Dominant 10
Reference #:  Q9Y698 (UniProtKB)
Alt. Names/Synonyms: CACNG2; calcium channel, voltage-dependent, gamma subunit 2; CCG2; MGC138502; MGC138504; Neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; Voltage-dependent calcium channel gamma-2 subunit
Gene Symbols: CACNG2
Molecular weight: 35,966 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Stargazin

Protein Structure Not Found.
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