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Protein Page:
FGF2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGF2 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Activator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4q26
Cellular Component: extracellular region; extracellular space
Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; ligand-dependent nuclear receptor transcription coactivator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: activation of MAPK activity; cell migration during sprouting angiogenesis; chemotaxis; embryonic morphogenesis; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; growth factor dependent regulation of satellite cell proliferation; hyaluronan catabolic process; inositol phosphate biosynthetic process; MAPKKK cascade; negative regulation of blood vessel endothelial cell migration; nervous system development; organ morphogenesis; phosphatidylinositol biosynthetic process; phosphoinositide-mediated signaling; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell fate specification; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of angiogenesis; regulation of phosphoinositide 3-kinase cascade; release of sequestered calcium ion into cytosol; somatic stem cell maintenance; ureteric bud branching; wound healing
Reference #:  P09038 (UniProtKB)
Alt. Names/Synonyms: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; BFGF; FGF2; FGFB; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; prostatropin
Gene Symbols: FGF2
Molecular weight: 30,770 Da
Basal Isoelectric point: 11.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGF2

Protein Structure Not Found.
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Sites Implicated In
cell differentiation, altered: S250‑p
cell growth, altered: S250‑p
molecular association, regulation: S250‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S62‑p PRSRAAGsPRtRGRR
0 1 T65‑p RAAGsPRtRGRRTEE
1 0 R82‑m2 SGSRLGDrGrGrALP
1 0 R84‑m2 SRLGDrGrGrALPGG
1 0 R86‑m2 LGDrGrGrALPGGRL
1 0 R96‑m2 PGGRLGGrGrGRAPE
1 0 R98‑m2 GRLGGrGrGRAPERV
1 0 R108‑m2 APERVGGrGrGrGTA
1 0 R110‑m2 ERVGGrGrGrGTAAP
1 0 R112‑m2 VGGrGrGrGTAAPRA
0 1 S138‑p AGTMAAGsITtLPAL
0 1 T141‑p MAAGsITtLPALPED
2 0 K168‑ac DPKRLYCkNGGFFLR
1 0 S206‑p AEERGVVsIKGVCAN
1 0 Y215 KGVCANRYLAMKEDG
0 1 K228‑ub DGRLLASkCVTDECF
1 2 Y245‑p ERLESNNyNTYRsRK
1 0 S250‑p NNyNTYRsRKytSWY
0 1 Y253‑p NTYRsRKytSWYVAL
1 1 T254‑p TYRsRKytSWYVALk
1 0 Y257 sRKytSWYVALkRTG
2 0 K261‑ac tSWYVALkRTGQYkL
1 0 K267‑ac LkRTGQYkLGSkTGP
1 0 K271‑ac GQYkLGSkTGPGQkA
2 0 K277‑ac SkTGPGQkAILFLPM
0 1 S285‑p AILFLPMsAKs____
0 2 S288‑p FLPMsAKs_______
  mouse

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____MAASGITSLPA
S8 MAASGITSLPALPED
K34 DPKRLYCKNGGFFLR
S72 AEERGVVSIKGVCAN
Y81‑p KGVCANRyLAMKEDG
K94 DGRLLASKCVTEECF
Y111‑p ERLESNNyNTYRSRK
S116 NNyNTYRSRKYSSWy
Y119 NTYRSRKYSSWyVAL
S120 TYRSRKYSSWyVALK
Y123‑p SRKYSSWyVALKRTG
K127 SSWyVALKRTGQYKL
K133 LKRTGQYKLGSKTGP
K137 GQYKLGSKTGPGQKA
K143 SKTGPGQKAILFLPM
S151 AILFLPMSAKS____
S154 FLPMSAKS_______
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S5 ___MAAGSITSLPAL
S8 MAAGSITSLPALPED
K34 DPKRLYCKNGGFFLR
S72 AEERGVVSIKGVCAN
Y81 KGVCANRYLAMKEDG
K94 DGRLLASKCVTEECF
Y111 ERLESNNYNTYRSRK
S116 NNYNTYRSRKYSSWY
Y119 NTYRSRKYSSWYVAL
S120 TYRSRKYSSWYVALK
Y123 SRKYSSWYVALKRTG
K127 SSWYVALKRTGQYKL
K133 LKRTGQYKLGSKTGP
K137 GQYKLGSKTGPGQKA
K143 SKTGPGQKAILFLPM
S151 AILFLPMSAKS____
S154 FLPMSAKS_______
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