a cytoplasmic microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. May mediate the conventional clathrin-mediated uptake of surface receptors. Expressed in the postsynaptic density of neuronal cells. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle; EC 188.8.131.52; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; G-protein coupled receptor internalization; G2/M transition of mitotic cell cycle; Golgi to plasma membrane transport; negative regulation of transforming growth factor beta receptor signaling pathway; neurite morphogenesis; positive regulation of apoptosis; positive regulation of nitric oxide biosynthetic process; positive regulation of phagocytosis; positive regulation of transcription, DNA-dependent; receptor internalization; receptor-mediated endocytosis; regulation of axon extension; regulation of nitric-oxide synthase activity; regulation of Rac protein signal transduction; regulation of transcription, DNA-dependent; response to cocaine; response to light stimulus; signal transduction; spermatogenesis; synaptic vesicle transport; transferrin transport
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.