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Protein Page:
H2A.1 (human)

Overview
H2A.1 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component: nuclear chromatin; nucleus
Molecular Function: DNA binding; enzyme binding; protein binding
Biological Process: chromatin silencing
Reference #:  P0C0S8 (UniProtKB)
Alt. Names/Synonyms: FLJ92027; H2A histone family, member C; H2A.1; H2A/c; H2A1; H2AFC; H2AFD; H2AFI; H2AFN; H2AFP; HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM; histone 1, H2ai; histone cluster 1, H2ai; Histone H2A type 1; Histone H2A/p
Gene Symbols: HIST1H2AI
Molecular weight: 13,960 Da
Basal Isoelectric point: 10.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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H2A.1

Protein Structure Not Found.
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