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Protein Page:
CD4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD4 Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: early endosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; external side of plasma membrane; integral to membrane; lipid raft; plasma membrane; T cell receptor complex
Molecular Function: coreceptor activity; enzyme binding; extracellular matrix structural constituent; glycoprotein binding; immunoglobulin binding; MHC class II protein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane receptor activity; viral receptor activity; zinc ion binding
Biological Process: adaptive immune response; cell surface receptor linked signal transduction; cytokine production; defense response to Gram-negative bacterium; entry into host cell; entry of virus into host cell; enzyme linked receptor protein signaling pathway; immune response; induction by virus of cell-cell fusion in host; innate immune response; maintenance of cellular protein localization; positive regulation of calcium-mediated signaling; positive regulation of interleukin-2 biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of T cell proliferation; regulation of defense response to virus by virus; regulation of T cell activation; response to estradiol stimulus; response to vitamin D; signal transduction; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; T cell selection; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
Disease: Okt4 Epitope Deficiency
Reference #:  P01730 (UniProtKB)
Alt. Names/Synonyms: CD4; CD4 antigen (p55); CD4 molecule; CD4 receptor; CD4mut; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
Gene Symbols: CD4
Molecular weight: 51,111 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD4

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S433‑p, S440‑p
protein degradation: S433‑p
receptor internalization, altered: S433‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S67‑p KILGNQGsFLtKGPs
0 1 T70‑p GNQGsFLtKGPsKLN
0 1 S74‑p sFLtKGPsKLNDRAD
0 3 - gap
3 1 S433‑p RRQAERMsQIkRLLs
0 1 K436‑ub AERMsQIkRLLsEKK
1 0 S440‑p sQIkRLLsEKKTCQC
0 2 K453‑ub QCPHRFQkTCSPI__
  CD4 iso2  
- gap
- gap
- gap
S18‑p PISSPRVsPFPPPAF
S254 RRQAERMSQIKRLLS
K257 AERMSQIKRLLSEKK
S261 SQIKRLLSEKKTCQC
K274 QCPHRFQKTCSPI__
  mouse

 
- gap
- gap
- gap
- gap
S432‑p QRQAARMsQIKRLLS
K435 AARMsQIKRLLSEKK
S439 sQIKRLLSEKKTCQC
K452 QCPHRMQKSHNLI__
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