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Protein Page:
CD4 (human)

CD4 Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: early endosome; endoplasmic reticulum membrane; external side of plasma membrane; lipid raft; plasma membrane
Molecular Function: enzyme binding; glycoprotein binding; MHC class II protein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane receptor activity; zinc ion binding
Biological Process: cell surface receptor linked signal transduction; entry into host cell; enzyme linked receptor protein signaling pathway; induction by virus of cell-cell fusion in host; maintenance of cellular protein localization; positive regulation of protein kinase activity; regulation of defense response to virus by virus; regulation of T cell activation; signal transduction; T cell costimulation; T cell differentiation; T cell receptor signaling pathway; T cell selection; viral envelope fusion with host membrane
Disease: Okt4 Epitope Deficiency
Reference #:  P01730 (UniProtKB)
Alt. Names/Synonyms: CD4; CD4 antigen (p55); CD4 molecule; CD4 receptor; CD4mut; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
Gene Symbols: CD4
Molecular weight: 51,111 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
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