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Protein Page:
EOMES (human)

Overview
EOMES Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4. Expressed in CD8+ T-cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 3p24.1
Cellular Component: nucleus
Molecular Function: chromatin binding; DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: adaptive immune response; brain development; cardioblast differentiation; CD8-positive, alpha-beta T cell differentiation during immune response; cerebral cortex neuron differentiation; cerebral cortex regionalization; endoderm formation; endodermal cell fate specification; interferon-gamma production; mesoderm formation; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb development; positive regulation of cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of neuron differentiation; stem cell maintenance; transcription, DNA-dependent; trophectodermal cell differentiation
Reference #:  O95936 (UniProtKB)
Alt. Names/Synonyms: EOMES; Eomesodermin homolog; eomesodermin homolog (Xenopus laevis); t box, brain, 2; T-box brain protein 2; T-brain-2; TBR-2; TBR2
Gene Symbols: EOMES
Molecular weight: 72,732 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EOMES

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S42‑p HLPSAAPsPQKLDLD
0 4 S107‑p PPDGRKGsPCGEEEL
0 2 S116‑p CGEEELPsAAAAAAA
0 4 S148‑p SERYYLQsPGPQGSE
0 1 S216‑p GPGAGAGsGAGGsSG
0 1 S221‑p AGsGAGGsSGGGGGP
0 1 T385‑p KGANNNNtQMIVLQS
0 3 - gap
0 2 - gap
0 1 - gap
0 2 S596‑p LPWTSRTsPTVFSED
0 2 T621‑p IGSSWIEtPPSIKsL
0 1 S627‑p EtPPSIKsLDSNDSG
0 2 S646‑p ACKRRRLsPsNSSNE
0 1 S648‑p KRRRLsPsNSSNENS
0 1 S657‑p SSNENSPsIKCEDIN
  EOMES iso3  
- gap
- gap
- gap
- gap
- gap
- gap
T90 KGANNNNTQMIVLQS
T176‑p ASENDRLtPsPTDSP
S178‑p ENDRLtPsPTDSPRS
T180 DRLtPsPTDSPRSHQ
S320 LPWTSRTSPTVFSED
T345 IGSSWIETPPSIKSL
S351 ETPPSIKSLDSNDSG
S370 ACKRRRLSPSNSSNE
S372 KRRRLSPSNSSNENS
S381 SSNENSPSIKCEDIN
  mouse

 
S52 LLPGAAPSPQRLDLD
S117‑p PPDGRKGsPCAEEEL
S126‑p CAEEELPsAATAAAT
S150 SERYYLPSPGPQGSE
S218 GPAAGSGSGAGSSGG
S223 SGSGAGSSGGGAGGP
T387 KGANNNNTQMIVLQS
T473‑p ASENDRLtPsPtDSP
S475‑p ENDRLtPsPtDSPRS
T477‑p DRLtPsPtDSPRSHQ
S617‑p LPWTSRMsPPVFPED
T642 ISSSWIETPPSIKSL
S648 ETPPSIKSLDSSDSG
S667 ACKRKRLSPSTPSNG
S669 KRKRLSPSTPSNGNS
P678 PSNGNSPPIKCEDIN
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