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Protein Page:
APOA4 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APOA4 May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Secreted; Endoplasmic reticulum; Lipid-binding; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: cell surface; chylomicron; cytosol; early endosome; endoplasmic reticulum lumen; extracellular region; extracellular space
Molecular Function: antioxidant activity; cholesterol binding; cholesterol transporter activity; copper ion binding; lipid binding; lipid transporter activity; phosphatidylcholine binding; protein binding; protein homodimerization activity
Biological Process: cellular protein metabolic process; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; fat-soluble vitamin metabolic process; hydrogen peroxide catabolic process; innate immune response in mucosa; leukocyte adhesion; lipid homeostasis; lipid transport; lipoprotein metabolic process; multicellular organismal lipid catabolic process; neurite regeneration; phosphatidylcholine metabolic process; phospholipid efflux; phototransduction, visible light; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; protein-lipid complex assembly; regulation of cholesterol absorption; regulation of cholesterol transport; removal of superoxide radicals; response to lipid hydroperoxide; retinoid metabolic process; reverse cholesterol transport; triacylglycerol catabolic process; vitamin metabolic process
Reference #:  P06727 (UniProtKB)
Alt. Names/Synonyms: Apo-AIV; ApoA-IV; APOA4; Apolipoprotein A-IV; Apolipoprotein A4; MGC142154; MGC142156
Gene Symbols: APOA4
Molecular weight: 45,399 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APOA4

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K51 EAVEHLQKSELTQQL
0 1 E119 RLLPHANEVSQKIGD
0 1 E136 RELQQRLEPYADQLR
0 1 A150 RTQVNTQAEQLRRQL
0 1 R154 NTQAEQLRRQLTPYA
0 1 K189 HADELKAKIDQNVEE
0 1 K247 GLTFQMKKNAEELKA
0 1 S259‑p LKARISAsAEELRQR
0 1 Y310‑p FRRRVEPyGENFNKA
0 3 A333 RQKLGPHAGDVEGHL
0 1 K345 GHLSFLEKDLRDKVN
0 1 K350 LEKDLRDKVNSFFST
0 1 E360 SFFSTFKEKESQDKT
0 1 K361 FFSTFKEKESQDKTL
  mouse

 
K51‑ac EAVEQFQkTDVTQQL
K119 RMMPHANKVTQTFGE
K136‑ac QKLQEHLkPYAVDLQ
T150‑p QDQINTQtQEMKLQL
K154 NTQtQEMKLQLTPYI
K189 LATNLKDKFNRNMEE
K247 GLAFQMKKNAEELQT
K259 LQTKVSAKIDQLQKN
M310 FRRTVEPMGEMFNKA
S333‑p RQQLGPNsGEVESHL
K345 SHLSFLEKSLREkVN
K350‑ac LEKSLREkVNSFMST
K360‑ac SFMSTLEkkGSPDQP
K361‑ac FMSTLEkkGSPDQPQ
  rat

 
K51 EAVEQLQKTDVTQQL
K119‑ac NMMPHANkVSQMFGD
R136 QKLQEHLRPYATDLQ
T150 QAQINAQTQDMkRQL
K154‑ac NAQTQDMkRQLTPYI
K189‑ac FANELKEkFNQNMEG
K247‑ac GLAFQMKkNAEELQT
N259 LQTKVSTNIDQLQKN
L310 FRRAVEPLGDKFNMA
S333‑p RQQLGSDsGDVESHL
K345‑ac SHLSFLEkNLREKVS
K350 LEkNLREKVSSFMST
K360 SFMSTLQKKGSPDQP
K361 FMSTLQKKGSPDQPL
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