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Protein Page:
SSTR1 (human)

Overview
SSTR1 Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Belongs to the G-protein coupled receptor 1 family. Interacts with SKB1. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell cycle regulation; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 14q13
Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane
Molecular Function: neuropeptide binding; somatostatin receptor activity
Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; cerebellum development; digestion; forebrain development; G-protein signaling, coupled to cyclic nucleotide second messenger; glutamate signaling pathway; negative regulation of cell proliferation; neuropeptide signaling pathway; response to nutrient; response to starvation; spermatogenesis
Reference #:  P30872 (UniProtKB)
Alt. Names/Synonyms: somatostatin receptor 1; Somatostatin receptor type 1; SRIF-2; SS-1-R; SS1-R; SS1R; SSR1; SSTR1
Gene Symbols: SSTR1
Molecular weight: 42,686 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SSTR1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T118‑p VPFLVTStLLRHWPF
0 1 S135‑p LLCRLVLsVDAVNMF
0 2 S364 ALKSRAYSVEDFQPE
0 2 S375 FQPENLESGGVFRNG
0 1 T383‑p GGVFRNGtCtSRITT
0 1 T385‑p VFRNGtCtSRITTL_
  mouse

 
T118 VPFLVTSTLLRHWPF
S135 LLCRLVLSVDAVNMF
S364‑p ALKSRAYsVEDFQPE
S375‑p FQPENLEsGGVFRNG
T383 GGVFRNGTCASRIST
A385 VFRNGTCASRISTL_
  rat

 
T118 VPFLVTSTLLRHWPF
S135 LLCRLVLSVDAVNMF
S364 ALKSRAYSVEDFQPE
S375 FQPENLESGGVFRNG
T383 GGVFRNGTCASRIST
A385 VFRNGTCASRISTL_
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