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Protein Page:
Epac1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Epac1 Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, misc.
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: apical part of cell; basal plasma membrane; brush border membrane; cell soma; cortical actin cytoskeleton; endomembrane system; filopodium; growth cone; lamellipodium; membrane; microvillus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein domain specific binding; Rap guanyl-nucleotide exchange factor activity
Biological Process: angiogenesis; blood coagulation; brain development; cAMP-mediated signaling; cell proliferation; energy reserve metabolic process; negative regulation of collagen biosynthetic process; platelet activation; positive regulation of angiogenesis; positive regulation of cAMP catabolic process; positive regulation of cell size; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription from RNA polymerase II promoter; Rap protein signal transduction; regulation of insulin secretion; response to nicotine; signal transduction; spinal cord development
Reference #:  O95398 (UniProtKB)
Alt. Names/Synonyms: 9330170P05Rik; bcm910; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; CGEF1; EPAC; EPAC 1; EPAC1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; RAPGEF3; RPGF3
Gene Symbols: RAPGEF3
Molecular weight: 103,751 Da
Basal Isoelectric point: 7.28  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Epac1

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S79 RWTPLTNSEEsLDFS
0 1 S82‑p PLTNSEEsLDFSESL
0 1 S267‑p VLLFEPHskAGTVLF
0 1 K268‑ac LLFEPHskAGTVLFS
0 1 K347 QDFNRIIKDVEAKTM
0 1 T380 AGPSRPPTPGRNRYT
0 3 S528 ENGCGNASPQMKARN
0 6 S864‑p SHNPVPLsPLRSRVS
0 1 S886 VARISTCSEQSLSTR
0 1 S889 ISTCSEQSLSTRSPA
  mouse

 
S79‑p RWTPLTNsEDSLDFR
S82 PLTNsEDSLDFRVSL
S267 VLLFEPHSKAGTVLF
K268 LLFEPHSKAGTVLFS
K347‑ub QDFNRIIkDVEAKTM
T380‑p AGPSRPPtPGRNRYT
S531‑p ENGCGNVsPQTKARN
S859‑p SHSTAPLsPLRSRVS
S881‑p GSRISTCsEQsLSTR
S884‑p ISTCsEQsLSTRSPA
  rat

 
S79 RWTPLTNSEGSLDFR
S82 PLTNSEGSLDFRVSL
S267 VLLFEPHSKAGTVLF
K268 LLFEPHSKAGTVLFS
K347 QDFNRIIKDVEAKTM
T380 AGPSRPPTPGRNRYT
S531‑p ENGCGNVsPQTKARN
S867 SHSTAPLSPLRSRVS
S889 ASRISTCSEQSLSTR
S892 ISTCSEQSLSTRSPA
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