Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
DLL3 (human)

Overview
DLL3 Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell development/differentiation
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: integral to membrane
Molecular Function: Notch binding
Biological Process: compartment specification; negative regulation of neurogenesis; Notch signaling pathway; paraxial mesoderm development; skeletal development; somitogenesis
Disease: Spondylocostal Dysostosis 1, Autosomal Recessive
Reference #:  Q9NYJ7 (UniProtKB)
Alt. Names/Synonyms: delta-like 3 (Drosophila); Delta-like protein 3; Delta3; DLL3; Drosophila Delta homolog 3; SCDO1
Gene Symbols: DLL3
Molecular weight: 64,618 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Select Structure to View Below

DLL3

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T119‑p FRDAWPGtFsFIIEt
0 1 S121‑p DAWPGtFsFIIEtWR
0 1 T126‑p tFsFIIEtWREELGD
0 1 T532‑p GSRLLAGtPEPSVHA
  mouse

 
T117 FRDAWPGTFSLVIET
S119 DAWPGTFSLVIETWR
T124 TFSLVIETWREQLGE
T530 GTRLLSGTREPSVHT
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.