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Protein Page:
Ugt1a6a (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ugt1a6a UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Carbohydrate Metabolism - ascorbate and aldarate; Membrane protein, integral; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - drug metabolism - other enzymes; Mitochondrial; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding
Biological Process: flavonoid biosynthetic process; xenobiotic metabolic process
Reference #:  P19224 (UniProtKB)
Alt. Names/Synonyms: GNT1; HLUGP; HLUGP1; MGC29860; Phenol-metabolizing UDP-glucuronosyltransferase; UD16; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT-1F; UGT1; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A6S; UGT1F
Gene Symbols: UGT1A6
Molecular weight: 60,751 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below

Ugt1a6a

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S50‑p KDIVEVLsDRGHEIV
0 1 I77 SKYYTRKIYPVPYDQ
0 1 Y91‑p QEELKNRyQsFGNNH
0 1 S93‑p ELKNRyQsFGNNHFA
0 1 Y220‑p LVNLLEPyLFyCLFs
0 2 Y223‑p LLEPyLFyCLFsKyE
0 1 S227‑p yLFyCLFsKyEELAS
0 1 Y229‑p FyCLFsKyEELASAV
0 12 K352 ANNTILVKWLPQNDL
0 1 K436‑ac VINDKSYkENIMRLS
  mouse

 
S50 KEIVEHLSERGHDIM
I77 SKYYRRKIFSVTYSL
F91 LEELQTRFRTFGNNH
T93 ELQTRFRTFGNNHFL
Y220 IVNILENYLYYCLYS
Y223 ILENYLYYCLYSKYE
S227 YLYYCLYSKYEIIAS
Y229 YYCLYSKYEIIASDL
K351‑ac AKNTILVkWLPQNDL
K435 VINNKSYKENIMRLS
  rat

 
S49 KEIVEHLSERGHDIV
S76‑p SKYYRRKsFPVPYNL
Y90 LEELRTRYRSFGNNH
S92 ELRTRYRSFGNNHFA
Y218 IANILENYLYHCLYS
H221 ILENYLYHCLYSKYE
S225 YLYHCLYSKYEILAS
Y227 YHCLYSKYEILASDL
K349‑ac AKNTILVkWLPQNDL
K433 VINNKSYKENIMRLS
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