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Protein Page:
Ugt1a6a (human)

Ugt1a6a UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function: glucuronosyltransferase activity; protein heterodimerization activity; protein homodimerization activity; retinoic acid binding
Biological Process: flavonoid biosynthetic process; xenobiotic metabolic process
Reference #:  P19224 (UniProtKB)
Alt. Names/Synonyms: GNT1; HLUGP; HLUGP1; MGC29860; Phenol-metabolizing UDP-glucuronosyltransferase; UD16; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT-1F; UGT1; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A6S; UGT1F
Gene Symbols: UGT1A6
Molecular weight: 60,751 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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