Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
Desmoplakin (human)

Overview
Desmoplakin Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p24
Cellular Component: cornified envelope; extracellular matrix; intermediate filament; nucleus; plasma membrane
Molecular Function: protein binding; protein binding, bridging; protein kinase C binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process: epidermis development; intermediate filament organization; keratinocyte differentiation; peptide cross-linking
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 8; Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma; Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis; Epidermolysis Bullosa, Lethal Acantholytic; Keratosis Palmoplantaris Striata Ii; Skin Fragility-woolly Hair Syndrome
Reference #:  P15924 (UniProtKB)
Alt. Names/Synonyms: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; desmoplakin I; desmoplakin II; DESP; DP; DPI; DPII; DSP
Gene Symbols: DSP
Molecular weight: 331,774 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Select Structure to View Below

Desmoplakin

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein