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Protein Page:
CAPN2 (human)

Overview
CAPN2 Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.53; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 1q41-q42
Cellular Component: cortical actin cytoskeleton; cytoplasm; cytosol; dendrite; endoplasmic reticulum; focal adhesion; Golgi apparatus; lipid raft; plasma membrane; pseudopodium
Molecular Function: calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity; protein binding
Biological Process: extracellular matrix disassembly; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of cytoskeleton organization and biogenesis
Reference #:  P17655 (UniProtKB)
Alt. Names/Synonyms: Calcium-activated neutral proteinase 2; Calpain 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; Calpain large polypeptide L2; Calpain M-type; calpain, large polypeptide L2; Calpain-2; Calpain-2 catalytic subunit; Calpain-2 large subunit; CAN2; CANP 2; CANP2; CANPL2; CANPml; CAPN2; FLJ39928; M-calpain; mCANP; Millimolar-calpain
Gene Symbols: CAPN2
Molecular weight: 79,995 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CAPN2

Protein Structure Not Found.
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