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Protein Page:
Fe65 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Fe65 adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Y142 (H2AXpY142) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as TIP60, probably explains its trancription activation activity. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Apoptosis; Transcription regulation
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: cell soma; cytoplasm; dendritic spine; growth cone; lamellipodium; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynaptic membrane; protein complex; synapse
Molecular Function: beta-amyloid binding; chromatin binding; histone binding; protein binding; protein complex binding; tau protein binding; transcription factor binding
Biological Process: apoptosis; axonogenesis; cell cycle arrest; DNA repair; double-strand break repair; negative regulation of cell growth; negative regulation of thymidylate synthase biosynthetic process; positive regulation of apoptosis; positive regulation of DNA repair; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to iron ion; signal transduction; transcription, DNA-dependent
Reference #:  O00213 (UniProtKB)
Alt. Names/Synonyms: adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Amyloid beta A4 precursor protein-binding family B member 1; amyloid beta A4 precursor protein-binding, family B, member 1; APBB1; FE65; MGC:9072; Protein Fe65; RIR; stat-like protein
Gene Symbols: APBB1
Molecular weight: 77,244 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Fe65

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: Y547‑p
intracellular localization: S610‑p
molecular association, regulation: Y547‑p, S610‑p
protein conformation: S610‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K48‑ub QATAVGPkDLRSAMG
0 1 P135 ANRGLRGPGLIISTQ
1 1 S175‑p EEEEDLSsPPGLPEP
0 1 S205‑p GPREHSKsASLLFGM
1 0 S228‑p DSSWATLsQGSPSYG
1 1 S287‑p WEPPGRAsPSQGSSP
1 3 S347‑p TFPAQSLsPEPLPQE
0 1 S459‑p VWGVGRDsGRERDFA
0 3 S517‑p RCLVNGLsLDHSKLV
2 1 Y547‑p VQKFQVYyLGNVPVA
2 0 S610‑p ECRVRFLsFLAVGRD
0 1 S666 QKCLDARSQASTSCL
0 1 S695‑p TVRRGVQsLWGsLKP
0 2 S699‑p GVQsLWGsLKPKRLG
1 3 T709‑p PKRLGAHtP______
  Fe65 iso2  
K48 QATAVGPKDLRSAMG
P135 ANRGLRGPGLIISTQ
S175 EEEEDLSSPPGLPEP
S205 GPREHSKSASLLFGM
S228 DSSWATLSQGSPSYG
S287 WEPPGRASPSQGSSP
S347 TFPAQSLSPEPLPQE
S459 VWGVGRDSGRDFAYV
S515 RCLVNGLSLDHSKLV
Y545 VQKFQVYYLGNVPVA
S608 ECRVRFLSFLAVGRD
S664 QKCLDARSQASTSCL
S693 TVRRGVQSLWGSLKP
S697 GVQSLWGSLKPKRLG
T707 PKRLGAHTP______
  mouse

 
K48‑ub QATAVVPkDLRSAMG
S135‑p ANRGLHGsALIINTQ
S175 EEEEDLSSPPGLPEP
S205 GPREHSKSASLLFGM
S228 DSSWATLSQGSPSYG
S287 WEPPGRASPSQGSSP
S347‑p SFPAQSLsPEPVPQE
S459 VWGVGRDSGSNRDFA
S517‑p RCLVNGLsLDHSKLV
Y547‑p VQKFQVYyLGNVPVA
S610 ECRVRFLSFLAVGRD
S666‑gl QKCLDARsQTSTSCL
S695 TVRRGVQSLWGsLKP
S699‑p GVQSLWGsLKPKRLG
T709‑p PKRLGSQtP______
  rat

 
K48 QATAVVPKDLRSAMG
S135 ANRGLHGSALIINTQ
S176 EEEEDLSSPQGLPEP
S206 GPREHSKSASLLFGM
S229 DSSWATLSQGSPSYG
S288 WEPPGRASPSQGNSP
S348 PFSAQSLSPEPVPQE
S460 VWGVGRDSGRERDFA
S518 RCLVNGLSLDHSKLV
Y548 VQKFQVYYLGNVPVA
S611‑p ECRVRFLsFLAVGRD
S667 QKCLDARSQTSTSCL
S696 TVRRGVQSLWGSLKP
S700 GVQSLWGSLKPKRLG
T710‑p PKRLGSQtP______
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