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Protein Page:
axin 2 (human)

Overview
axin 2 is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q24.1
Cellular Component: beta-catenin destruction complex; cell cortex; centrosome; cytoplasm; cytoplasmic microtubule; cytosol; Golgi apparatus; microtubule cytoskeleton; nucleoplasm; nucleus; plasma membrane; postsynaptic density
Molecular Function: beta-catenin binding; enzyme binding; GTPase activator activity; protein kinase binding; ubiquitin protein ligase binding
Biological Process: dorsal/ventral axis specification; intramembranous ossification; maintenance of DNA repeat elements; mRNA stabilization; negative regulation of cell proliferation; negative regulation of osteoblast differentiation; odontogenesis; positive regulation of protein amino acid phosphorylation; regulation of mismatch repair; regulation of transcription, DNA-dependent; Wnt receptor signaling pathway
Disease: Oligodontia-colorectal Cancer Syndrome
Reference #:  Q9Y2T1 (UniProtKB)
Alt. Names/Synonyms: Axil; axin 2; Axin-2; Axin-like protein; AXIN2; Axis inhibition protein 2; AXN2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Gene Symbols: AXIN2
Molecular weight: 93,558 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

axin 2

Protein Structure Not Found.


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