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Protein Page:
Doublecortin (human)

Overview
Doublecortin Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of a overlapping, but distinct, signaling pathways that promote neuronal migration. Interacts with tubulin. Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq22.3-q23
Cellular Component: cytoplasm; cytoskeleton; cytosol; microtubule associated complex; neuron projection; nucleus
Molecular Function: calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; microtubule binding; protein binding; protein kinase binding
Biological Process: central nervous system development; nervous system development; neuron migration; peptidyl-serine phosphorylation; protein amino acid autophosphorylation
Disease: Lissencephaly, X-linked, 1
Reference #:  O43602 (UniProtKB)
Alt. Names/Synonyms: DBCN; DC; DCX; doublecortex; doublecortin; Doublin; Lis-X; Lissencephalin-X; LISX; Neuronal migration protein doublecortin; SCLH; XLIS
Gene Symbols: DCX
Molecular weight: 40,574 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Doublecortin

Protein Structure Not Found.
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